Damaged DNA is an obstacle during DNA replication and a cause of genome instability and
cancer. To bypass this problem, eukaryotes activate DNA damage tolerance (DDT) …

DNA damage may compromise genome integrity and lead to cell death. Cells have evolved
a variety of processes to respond to DNA damage including damage repair and tolerance …

Failure of cells to process toxic double-strand breaks (DSBs) constitutes a major intrinsic
source of genome instability, a hallmark of cancer. In contrast with interphase of the cell …

DNA damage is a constant source of stress challenging genomic integrity. To ensure faithful
duplication of our genomes, mechanisms have evolved to deal with damage encountered …

Exo1-mediated resection of DNA double-strand break ends generates 3′ single-stranded
DNA overhangs required for homology-based DNA repair and activation of the ATR …

Problems during DNA replication underlie genomic instability and drive malignant
transformation. The DNA damage checkpoint stabilizes stalled replication forks thus …

Genomic DNA is under constant attack from both endogenous and exogenous sources of
DNA damaging agents. Without proper care, the ensuing DNA damages would lead to …

DNA-end resection, the generation of single-stranded DNA at DNA double strand break
(DSB) ends, is critical for controlling the many cellular responses to breaks. Here we show …

Checkpoints monitor critical cell cycle events such as chromosome duplication and
segregation. They are highly conserved mechanisms that prevent progression into the next …

The repair of DNA lesions that occur endogenously or in response to diverse genotoxic
stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways …