Background—The natural histories of equally severe symptomatic and asymptomatic carotid
stenoses are very different, which suggests dichotomy in plaque behavior. The vascular …

Background and Purpose—To determine the relationship between ulceration, thrombus,
and calcification of carotid artery atherosclerotic plaques and symptoms of ipsilateral or …

Objective—Rupture of unstable atherosclerotic plaques is the pathological substrate for
acute ischemic events. Underlying cellular and molecular characteristics of plaque rupture …

Abstract STROKE IS THE third leading cause of death in the United States, constituting
approximately 700,000 cases each year, of which about 500,000 are first attacks and …

Background—Atherosclerotic plaque at the carotid bifurcation is often associated with
transient ischemic attack (TIA) and ischemic stroke, but the mechanisms are not completely …

OBJECTIVES:: To study the relationship between carotid plaque morphology and the
degree of stenosis on Duplex ultrasonography and symptoms. DESIGN:: Prospective open …

Background and Purpose—Rates of incident and recurrent cardiovascular events rise
steadily with age, due partly to more extensive atherosclerotic burden. However, in patients …

Purpose: Plaque rupture is often the precipitating event in acute coronary syndromes. We
hypothesized that a similar process occurs in stenotic carotid plaques in association with …

Purpose: The structural features that underlie carotid plaque disruption and symptoms are
largely unknown. We have previously shown that the chemical composition and structural …

To determine the natural history of changes in plaque morphology and luminal diameter of
atherosclerotic carotid arteries, we used duplex scanning to follow-up (1) the contralateral …