Centchroman prevents metastatic colonization of breast cancer cells and disrupts angiogenesis via inhibition of RAC1/PAK1/β-catenin signaling axis

S Khan, S Shukla, M Farhan, S Sinha, AD Lakra… - Life Sciences, 2020 - Elsevier
Aims We have previously reported that Centchroman (CC), an oral contraceptive drug,
inhibits breast cancer progression and metastasis. In this study, we investigated whether CC …

Centchroman suppresses breast cancer metastasis by reversing epithelial–mesenchymal transition via downregulation of HER2/ERK1/2/MMP-9 signaling

S Khan, S Shukla, S Sinha, AD Lakra, HK Bora… - … International Journal of …, 2015 - Elsevier
Metastatic spread during carcinogenesis worsens disease prognosis and accelerates the
cancer progression. Therefore, newer therapeutic options with higher specificity toward …

Centchroman regulates breast cancer angiogenesis via inhibition of HIF-1α/VEGFR2 signalling axis

J Dewangan, S Kaushik, SK Rath, AK Balapure - Life sciences, 2018 - Elsevier
Aims Angiogenesis is a recognized hallmark of cancer which promotes cancer cell
progression and metastasis. Inhibition of angiogenesis to attenuate cancer growth is …

Xiao-ai-ping injection enhances effect of paclitaxel to suppress breast cancer proliferation and metastasis via activating transcription factor 3

J Chen, X Zhang, X Xiao, Y Ding… - Integrative Cancer …, 2020 - journals.sagepub.com
Chemotherapy is an effective treatment for invasive breast cancer. Paradoxically, many
recently published findings showed that the first-line chemotherapeutic agent paclitaxel …

Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines

S Kumari, AK Badana, GM Mohan, GS Naik… - Biomedicine & …, 2017 - Elsevier
Breast cancer is one of the most frequently diagnosed cancer in woman. Triple-negative
breast cancer (TNBC) is most aggressive form of breast cancer. There is a growing interest …

Cryptanshinone inhibits the glycolysis and inhibits cell migration through PKM2/β-catenin axis in breast cancer

J Zhou, CM Su, HA Chen, S Du, CW Li… - OncoTargets and …, 2020 - Taylor & Francis
Background Breast cancer is one of the most prevalent gynecologic malignancies
worldwide. Despite the high sensitivity in response to chemotherapy, drug resistance …

Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/β‐catenin signaling cascades and reversal of …

S Shrivastava, MK Jeengar, D Thummuri, A Koval… - Biofactors, 2017 - Wiley Online Library
Cardamonin (CD), an active chalconoid, has shown potent anticancer effects in preclinical
studies; however, the effect and underlying mechanism of CD for the treatment of triple …

[RETRACTED ARTICLE] Baicalein restrains proliferation, migration, and invasion of human malignant melanoma cells by down-regulating colon cancer associated …

X Yang, J Jiang, C Zhang, Y Li - Brazilian Journal of Medical and …, 2019 - SciELO Brasil
Baicalein (BAI) is an acknowledged flavonoids compound, which is regarded as a useful
therapeutic pharmaceutical for numerous cancers. However, its involvement in melanoma is …

Uncovering the Anti-Angiogenic Mechanisms of Centella asiatica via Network Pharmacology and Experimental Validation

B Zhao, Y Li, B Wang, J Liu, Y Yang, Q Quan, Q An… - Molecules, 2024 - mdpi.com
Background: Centella asiatica (CA) has been used to address cancer for centuries in
traditional Chinese medicine (TCM). Previous studies demonstrated its anti-angiogenesis …

Zhuidu Formula suppresses the migratory and invasive properties of triple-negative breast cancer cells via dual signaling pathways of RhoA/ROCK and CDC42 …

Q Wu, X Ma, Z Jin, R Ni, Y Pan, G Yang - Journal of Ethnopharmacology, 2023 - Elsevier
Abstract Ethnopharmacological relevance Zhuidu Formula (ZDF) is composed of triptolide,
cinobufagin and paclitaxel, which are the active ingredients of Tripterygium wilfordii Hook. F …