Development of white matter hyperintensity is preceded by reduced cerebrovascular reactivity

K Sam, AP Crawley, J Conklin, J Poublanc… - Annals of …, 2016 - Wiley Online Library
Objective White matter hyperintensities (WMH) observed on neuroimaging of elderly
individuals are associated with cognitive decline and disability. However, the pathogenesis …

Cerebral perfusion and cerebrovascular reactivity are reduced in white matter hyperintensities

JR Marstrand, E Garde, E Rostrup, P Ring… - Stroke, 2002 - Am Heart Assoc
Background and Purpose—There is growing evidence that white matter hyperintensities
(WMH) should not be considered as benign age-dependent changes on MR images but …

Progression of white matter hyperintensities preceded by heterogeneous decline of microstructural integrity

EMC Van Leijsen, MI Bergkamp, IWM Van Uden… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—White matter hyperintensities (WMH) are frequently seen on
neuroimaging of elderly and are associated with cognitive decline and the development of …

[HTML][HTML] Characterizing the white matter hyperintensity penumbra with cerebral blood flow measures

N Promjunyakul, D Lahna, JA Kaye, HH Dodge… - NeuroImage: Clinical, 2015 - Elsevier
Abstract Objective White matter hyperintensities (WMHs) are common with age, grow over
time, and are associated with cognitive and motor impairments. Mechanisms underlying …

[HTML][HTML] White matter hyperintensities and normal-appearing white matter integrity in the aging brain

SM Maniega, MCV Hernández, JD Clayden… - Neurobiology of …, 2015 - Elsevier
White matter hyperintensities (WMH) of presumed vascular origin are a common finding in
brain magnetic resonance imaging of older individuals and contribute to cognitive and …

White matter hyperintensities, cognitive impairment and dementia: an update

ND Prins, P Scheltens - Nature Reviews Neurology, 2015 - nature.com
White matter hyperintensities (WMHs) in the brain are the consequence of cerebral small
vessel disease, and can easily be detected on MRI. Over the past three decades, research …

The effect of white matter hyperintensities on neurodegeneration in mild cognitive impairment

G Tosto, ME Zimmerman, JL Hamilton… - Alzheimer's & …, 2015 - Elsevier
Introduction It is unclear whether white matter hyperintensities (WMHs), magnetic resonance
imaging markers of small-vessel cerebrovascular disease, promote neurodegeneration and …

The impact of magnetic resonance imaging-detected white matter hyperintensities on longitudinal changes in regional cerebral blood flow

MA Kraut, LL Beason-Held… - Journal of Cerebral …, 2008 - journals.sagepub.com
White matter hyperintensities are frequently detected on cranial magnetic resonance
imaging (MRI) scans of older adults. Given the presumed ischemic contribution to the …

Cerebral small vessel disease in aging and A lzheimer's disease: a comparative study using MRI and SPECT

I Makedonov, SE Black… - European journal of …, 2013 - Wiley Online Library
Background White matter hyperintensities (WMH) are associated with aging and are
prevalent in various brain pathologies. The purpose of the current study was to characterize …

Regional white matter hyperintensities: aging, Alzheimer's disease risk, and cognitive function

AC Birdsill, RL Koscik, EM Jonaitis, SC Johnson… - Neurobiology of …, 2014 - Elsevier
White matter hyperintensities (WMH) of presumed vascular origin, as seen on T2-weighted
fluid attenuated inversion recovery magnetic resonance imaging, are known to increase with …