Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …

Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …

Alzheimer's disease (AD)(MIM: 104300) is a highly heritable disease with great complexity
in its genetic contributors, and represents the most common form of dementia. With the …

Alzheimer's disease (AD) represents the main form of dementia, and is a major public health
problem. Despite intensive research efforts, current treatments have only marginal …

Polygenic risk scores (PRSs) have been used to combine the effects of variants with small
effects identified by genome-wide association studies. We explore the potential for using …

In addition to apolipoprotein E (APOE), recent large genome-wide association studies
(GWASs) have identified nine other genes/loci (CR1, BIN1, CLU, PICALM, MS4A4/MS4A6E …

Over the past decade, research aiming to disentangle the genetic underpinnings of late-
onset Alzheimer's disease has mostly focused on the identification of common variants …

Linkage studies, candidate gene and whole-genome association studies have resulted in a
tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the …