Metallothionein prevents high-fat diet–induced cardiac contractile dysfunction: role of peroxisome proliferator–activated receptor γ coactivator 1α and mitochondrial …
Obesity is associated with oxidative stress and mitochondrial and myocardial dysfunction,
although interaction among which remains elusive. This study was designed to evaluate the …
although interaction among which remains elusive. This study was designed to evaluate the …
[HTML][HTML] Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: role of Akt phosphorylation, PTB1B, PPARγ and c-Jun
Aims/hypothesis Insulin resistance is concomitant with metabolic syndrome, oxidative stress
and cardiac contractile dysfunction. However, the causal relationship between oxidative …
and cardiac contractile dysfunction. However, the causal relationship between oxidative …
Metallothionein antagonizes aging‐induced cardiac contractile dysfunction: role of PTP1B, insulin receptor tyrosine phosphorylation and Akt
Aging is often accompanied by reduced insulin sensitivity and cardiac dysfunction. However,
the causal relationship between the two remains poorly understood. This study was …
the causal relationship between the two remains poorly understood. This study was …
[HTML][HTML] Cardiac-specific overexpression of metallothionein rescues against cigarette smoking exposure-induced myocardial contractile and mitochondrial damage
Objectives Second hand cigarette smoke is an independent risk factor for cardiovascular
disease. Although a tie between smoking and cardiovascular disease is well established …
disease. Although a tie between smoking and cardiovascular disease is well established …
Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production
G Ye, NS Metreveli, J Ren, PN Epstein - Diabetes, 2003 - Am Diabetes Assoc
Many individuals with diabetes experience impaired cardiac contractility that cannot be
explained by hypertension and atherosclerosis. This cardiomyopathy may be due to either …
explained by hypertension and atherosclerosis. This cardiomyopathy may be due to either …
Cardiac overexpression of metallothionein rescues cold exposure-induced myocardial contractile dysfunction through attenuation of cardiac fibrosis despite …
Cold exposure is associated with an increased prevalence of cardiovascular disease
although the mechanism is unknown. Metallothionein, a heavy-metal-scavenging …
although the mechanism is unknown. Metallothionein, a heavy-metal-scavenging …
Heavy metal scavenger metallothionein attenuates ER stress-induced myocardial contractile anomalies: role of autophagy
L Yang, N Hu, S Jiang, Y Zou, J Yang, L Xiong, J Ren - Toxicology letters, 2014 - Elsevier
Endoplasmic reticulum (ER) stress increases the risk of cardiovascular morbidity and
mortality although the underlying mechanism remains elusive. This study was designed to …
mortality although the underlying mechanism remains elusive. This study was designed to …
Peroxisome proliferator-activated receptor β/δ activation in adult hearts facilitates mitochondrial function and cardiac performance under pressure-overload condition
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is an essential transcription factor
in myocardial metabolism. This study aims to investigate the effects of PPARβ/δ activation in …
in myocardial metabolism. This study aims to investigate the effects of PPARβ/δ activation in …
Heavy metal scavenger metallothionein mitigates deep hypothermia-induced myocardial contractile anomalies: role of autophagy
S Jiang, R Guo, Y Zhang, Y Zou… - American Journal of …, 2013 - journals.physiology.org
Low-ambient temperature environment exposure increased the risk of cardiovascular
morbidity and mortality, although the underlying mechanism remains unclear. This study …
morbidity and mortality, although the underlying mechanism remains unclear. This study …
Metallothionein abrogates GTP cyclohydrolase I inhibition–induced cardiac contractile and morphological defects: role of mitochondrial biogenesis
AF Ceylan-Isik, KK Guo, EC Carlson, JR Privratsky… - …, 2009 - Am Heart Assoc
One key mechanism for endothelial dysfunction is endothelial NO synthase (eNOS)
uncoupling, whereby eNOS generates O2•− rather than NO because of deficient eNOS …
uncoupling, whereby eNOS generates O2•− rather than NO because of deficient eNOS …