We have synthesized twenty-three 1, 4-dihydropyridine derivatives (1, 4-DHPs) by using a
microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their …

A series of dihydropyrido [2, 3-d] pyrimidines have been synthesized and screened for its in
vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 2a …

Leishmaniasis and Chagas' disease constitute a relevant health and socio-economic
problem in Latin America, Africa, and Asia. The therapeutic interventions rely on inefficient …

The antileishmanial activity of a series of bis-pyridinium derivatives that are analogues of
pentamidine have been investigated, and all compounds assayed were found to display …

Abstract Several new substituted 1, 2, 3, 4-tetrahydropyrimidine derivatives 2a–h have been
synthesized by the modified Biginelli and Hantzsch reactions and compounds were …

Leishmania mexicana promastigote and intracellular amastigote growths were inhibited by
the water-soluble furan-2-carboxamide issued from the pharmacophore 2-amino-4, 6 …

A series of piperazinyl-β-carboline-3-carboxamide derivatives were designed through a
molecular hybridization approach. Designed analogues were synthesized, characterized …

In this work, we report the antileishmanial activity of 23 compounds based on 2‐pyrazyl and
2‐pyridylhydrazone derivatives. The compounds were tested against the promastigotes of …

Background and purpose: The prevalence of leishmaniasis is reported in more than 98
countries and Iran is one of the endemic areas. There is no vaccine for this disease and few …

Abstract New 1, 3 dibenzyl-tetrahydropyridinylidene ammonium salts have been prepared
from unsubstituted or N-benzylated tetrahydropyridinylidene ammonium salts. The …