Protein delivery into cells is a potentially transformative tool for treating “undruggable”
targets in diseases associated with protein deficiencies or mutations. The vast majority of …

Intracellular delivery of proteins is potentially a game-changing approach for therapeutics.
However, for most applications, the protein needs to access the cytosol to be effective. A …

Achieving the full potential of therapeutic proteins to access and target intracellular receptors
will have enormous benefits in advancing human health and fighting disease. Existing …

Introducing exogenous proteins intracellularly presents tremendous chances in scientific
research and clinical applications. The effectiveness of this method, however, has been …

Protein-based therapeutics have made a significant impact in the treatment of a variety of
important human diseases. However, given their intrinsically vulnerable structure and …

Cytosolic delivery of bioactive agents has exhibited great potential to cure undruggable
targets and diseases. Because biological cell membranes are a natural barrier for living …

Despite recent advances in nanomaterial-based delivery systems, their applicability as
carriers of cargo, especially proteins for targeting cellular components and manipulating cell …

Nanocarriers are designed to specifically accumulate in diseased tissues. In this context,
targeting of intracellular compartments was shown to enhance the efficacy of many drugs …

Gene therapy has been used as a potential approach to address the diagnosis and
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …

Proteins play a crucial role in life, taking part in all vital processes in the body. In the past
decade, there was increasing interest in delivering active forms of proteins to specific cells …