Natural allies for heart health: Nrf2 Activation and cardiovascular disease management

SU Khan, SU Khan, M Suleman, MU Khan… - Current Problems in …, 2024 - Elsevier
The term “cardiovascular diseases”(CVD) refers to various ailments that affect the heart and
blood vessels, including myocardial ischemia, congenital heart defects, heart failure …

Activation of Nrf2 signaling: A key molecular mechanism of protection against cardiovascular diseases by natural products

X Wu, J Wei, Y Yi, Q Gong, J Gao - Frontiers in Pharmacology, 2022 - frontiersin.org
Cardiovascular diseases (CVD) are a group of cardiac and vascular disorders including
myocardial ischemia, congenital heart disease, heart failure, hypertension, atherosclerosis …

Targeting the Nrf2 pathway against cardiovascular disease

J Li, T Ichikawa, JS Janicki, T Cui - Expert opinion on therapeutic …, 2009 - Taylor & Francis
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that controls the basal and
inducible expression of a battery of antioxidant genes and other cytoprotective Phase II …

NRF2 in cardiovascular diseases: a ray of hope!

R Vashi, BM Patel - Journal of cardiovascular translational research, 2021 - Springer
Heart failure is a worldwide pandemic influencing 26 million individuals worldwide and is
expanding. Imbalanced redox homeostasis in cardiac cells alters the structure and function …

Nrf2 and Cardiovascular Defense

R Howden - Oxidative medicine and cellular longevity, 2013 - Wiley Online Library
The cardiovascular system is susceptible to a group of diseases that are responsible for a
larger proportion of morbidity and mortality than any other disease. Many cardiovascular …

Nrf2-mediated dichotomy in the vascular system: Mechanistic and therapeutic perspective

W Wu, A Hendrix, S Nair, T Cui - Cells, 2022 - mdpi.com
Nuclear factor-erythroid 2-related factor 2 (Nrf2), a transcription factor, controls the
expression of more than 1000 genes that can be clustered into different categories with …

[HTML][HTML] Nrf2 for a key member of redox regulation: A novel insight against myocardial ischemia and reperfusion injuries

X Han, H Wang, F Du, X Zeng, C Guo - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Nuclear factor erythroid-2 related factor 2 (Nrf2), a nuclear transcription factor, modulates
genes responsible for antioxidant responses against toxic and oxidative stress to maintain …

The role of Nrf2 in cardiovascular function and disease

S Satta, AM Mahmoud, FL Wilkinson… - Oxidative medicine …, 2017 - Wiley Online Library
Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …

The role of Nrf2‐mediated pathway in cardiac remodeling and heart failure

S Zhou, W Sun, Z Zhang… - Oxidative medicine and …, 2014 - Wiley Online Library
Heart failure (HF) is frequently the consequence of sustained, abnormal neurohormonal,
and mechanical stress and remains a leading cause of death worldwide. The key …

The dark side of Nrf2 in the heart

H Zang, RO Mathew, T Cui - Frontiers in physiology, 2020 - frontiersin.org
Nuclear factor-erythroid factor 2-related factor 2 (Nrf2) is a critical transcription factor that
regulates the expression of over 1000 genes in the cell under normal and stressed …