The Cyclitol L-(+)-bornesitol as an active marker for the cardiovascular activity of the brazilian medicinal plant Hancornia speciosa

LN Moreira, GC Silva, DV Câmara… - Biological and …, 2019 - jstage.jst.go.jp
The cyclitol bornesitol is the main constituent of the leaves from the antihypertensive
medicinal plant Hancornia speciosa. This study aimed to investigate the ability of bornesitol …

[HTML][HTML] Potent antihypertensive effect of Hancornia speciosa leaves extract

GC Silva, FC Braga, VS Lemos, SF Cortes - Phytomedicine, 2016 - Elsevier
Abstract Background Hancornia speciosa Gomes is an herb traditionally used in Brazil for
blood pressure control. Purpose The present work investigated the antihypertensive effect of …

[HTML][HTML] Hancornia speciosa Gomes induces hypotensive effect through inhibition of ACE and increase on NO

GC Silva, FC Braga, MP Lima, JL Pesquero… - Journal of …, 2011 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Hancornia speciosa Gomes are
popularly used in Brazil to treat diabetes and hypertension. Cardiovascular diseases are the …

[HTML][HTML] Determination of L-(+)-bornesitol, the hypotensive constituent of Hancornia speciosa, in rat plasma by LC-MS/MS and its application on a pharmacokinetic …

LN Moreira, C Feltrin, JE Goncalves… - Biomedicine & …, 2020 - Elsevier
Hancornia speciosa is a medicinal plant with proven antihypertensive activity. The cyclitol l-
(+)-bornesitol is the main constituent of its leaves and is a potent inhibitor of the angiotensin …

Nitric oxide-dependent vasodilatation by ethanolic extract of Hancornia speciosa via phosphatidyl-inositol 3-kinase

HC Ferreira, CP Serra, VS Lemos, FC Braga… - Journal of …, 2007 - Elsevier
The vasodilator effect of the ethanolic extract of leaves from Hancornia speciosa Gomes
(HSE) was studied in rat aortic rings. HSE produced a concentration-dependent …

Forced degradation of L-(+)-bornesitol, a bioactive marker of Hancornia speciosa: Development and validation of stability indicating UHPLC-MS method and effect of …

JH de Sousa Gomes, GC da Silva, SF Côrtes… - … of Chromatography B, 2018 - Elsevier
The antihypertensive activity of the medicinal plant Hancornia speciosa has been previously
demonstrated by us, being the activity ascribed to polyphenols and cyclitols like l-(+) …

Development and validation of an HPLC-DAD method for quantification of bornesitol in extracts from Hancornia speciosa leaves after derivatization with p …

ABD Pereira, TM Veríssimo, MA de Oliveira… - … of Chromatography B, 2012 - Elsevier
Cylitol l-(+)-bornesitol is regarded as a bioactive constituent from Hancornia speciosa
leaves, a plant species traditionally used in Brazil to treat diabetes and hypertension. We …

Diuretic, natriuretic and potassium-sparing effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats

CLB de Almeida, T Boeing, LB Somensi… - Chemico-Biological …, 2017 - Elsevier
Active constituents from natural origin have long been used for the treatment of patients
suffering from cardiovascular and renal diseases. This study therefore aimed to investigate …

[HTML][HTML] Calcium influx inhibition is involved in the hypotensive and vasorelaxant effects induced by yangambin

IGA Araújo, DF Silva, MC de Alustau, KLG Dias… - Molecules, 2014 - mdpi.com
The pharmacological effects on the cardiovascular system of yangambin, a lignan isolated
from Ocotea duckei Vattimo (Lauraceae), were studied in rats using combined functional …

[HTML][HTML] Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit

MT Páez, DC Rodríguez, DF López… - Brazilian Journal of …, 2013 - SciELO Brasil
Croton schiedeanus Schltd (NV:" almizclillo") is a plant used in traditional medicine as an
antihypertensive in Colombia. It contains flavonoid, diterpenoid and fenilbutanoid …