How to explain embryological development? This question has received different answers
since the renaissance of epigenesis in the middle of the 18th century. A majority of present …

Advanced genomics tools enable powerful new strategies for understanding complex
biological processes, including development. By extension, we should be able to use these …

Organismal phenotypes result largely from inherited developmental programs, usually
executed during embryonic and juvenile life stages. These programs are not blank slates …

The next quantum leap in understanding evolution is overdue: and it can only be made by
developing the model of gene regulatory networks (GRNs) as the units that integrate a …

Cascades of transcriptional regulation are the common source of the forward drive in all
developmental systems. Increases in complexity and specificity of gene expression at …

An important contribution of systems biology is the insight that biological systems depend on
the function of molecular interactions and not just on individual molecules. System level …

The core of gene regulatory networks (GRNs) is formed by transcription factors (TF) and cis–
regulatory modules (CRMs) present in their downstream genes. GRNs have a modular …

Over the last few years an intense activity in the areas of advanced microscopy and
quantitative cell biology has put the focus on the morphogenetic events that shape embryos …

Keywords: animals; cis-regulatory element; development; evolution; gene regulatory
networks; metazoa; morphology; transcription factor EN animals cis-regulatory element …

This talk will concern the gene regulatory network (GRN) for endomesoderm specification in
sea urchin embryos. The network, which now contains 50 genes, mainly regulatory genes, is …