Abstract Background and Aims: Alcohol-associated liver disease (ALD) accounts for 70% of
liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial …

Alcohol-induced liver disease (ALD) is a major health concern of alcohol abuse and a
leading cause of liver-related morbidity and mortality. The pathogenesis of ALD is …

Background Chronic ethanol (EtOH) consumption is a major cause of liver disease
worldwide. Oxidative stress is a known consequence of EtOH metabolism and is thought to …

Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with
an estimated 25% worldwide prevalence. No drugs have yet been approved and NAFLD …

Alcohol-related liver disease (ALD) is a spectrum of liver alterations both at the structural
and functional levels that begins with the deposition of lipids in hepatocytes defining the first …

Alcoholic liver disease (ALD) is a global concern affecting most of the population and
leading to the development of end‐stage liver disease. Metabolic alterations due to …

Mitochondria are intracellular organelles responsible for energy production, glucose and
lipid metabolism, cell death, cell proliferation, and innate immune response. Mitochondria …

Background & Aims Mitochondria are the major organelles for the formation of reactive
oxygen species (ROS) in the cell, and mitochondrial dysfunction has been described as a …

Alcohol abuse is the leading cause of liver related morbidity and mortality. Chronic or binge
alcohol drinking causes hepatic steatosis which can develop to steatohepatitis, cirrhosis and …

Background Patients with acute alcohol‐associated hepatitis (AH) have immune
dysfunction. Mitochondrial function is critical for immune cell responses and regulates …