Biguanide-Derived Polymeric Nanoparticles Kill MRSA Biofilm and Suppress Infection In Vivo

J Li, W Zhong, K Zhang, D Wang, J Hu… - … applied materials & …, 2020 - ACS Publications
Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of drug-resistant
infections. Its propensity to develop biofilms makes it especially resistant to conventional …

Natural antibacterial agent-based nanoparticles for effective treatment of intracellular MRSA infection

X Zou, S Cai, T Wang, S Zheng, X Cui, J Hao, X Chen… - Acta Biomaterialia, 2023 - Elsevier
Intracellular MRSA is extremely difficult to eradicate by traditional antibiotics, leading to
infection dissemination and drug resistance. A general lack of facile and long-term strategies …

pH-Responsive Swelling Micelles for the Treatment of Methicillin-Resistant Staphylococcus aureus Biofilms

C Deusenbery, C Gomez Casas… - ACS Applied Polymer …, 2023 - ACS Publications
Biofilm formation exacerbates the challenge of eradicating drug-resistant bacterial
infections. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major …

Synergy of Antibiotics and Antibiofilm Agents against Methicillin-Resistant Staphylococcus aureus Biofilms

C Deusenbery, O Carneiro, C Oberkfell… - ACS Infectious …, 2023 - ACS Publications
Methicillin-resistant Staphylococcus aureus (MRSA) infections are some of the most
common antibiotic-resistant infections, often exacerbated by the formation of biofilms. Here …

Inhibition of methicillin-resistant Staphylococcus aureus (MRSA) biofilm by cationic poly (D, L-lactide-co-glycolide) nanoparticles

Y Qiu, Y Wu, B Lu, G Zhu, T Gong, R Wang, Q Peng… - Biofouling, 2020 - Taylor & Francis
The emergent need for new treatment methods for multi-drug resistant pathogens such as
methicillin-resistant Staphylococcus aureus (MRSA) has focused attention on novel potential …

Biocompatible nanocarrier fortified with a dipyridinium-based amphiphile for eradication of biofilm

S Goswami, D Thiyagarajan, G Das… - ACS applied materials …, 2014 - ACS Publications
Annihilation of bacterial biofilms is challenging owing to their formidable resistance to
therapeutic antibiotics and thus there is a constant demand for development of potent …

Tailoring Nanoparticle-Biofilm Interactions to Increase the Efficacy of Antimicrobial Agents Against Staphylococcus aureus

S Fulaz, H Devlin, S Vitale, L Quinn… - International journal …, 2020 - Taylor & Francis
Background Considering the timeline required for the development of novel antimicrobial
drugs, increased attention should be given to repurposing old drugs and improving …

Antibody-functionalized polymer nanoparticles for targeted antibiotic delivery in models of pathogenic bacteria infecting human macrophages

LG Miranda Calderon, T Alejo, S Santos… - … Applied Materials & …, 2023 - ACS Publications
The efficacy of antibody-functionalized poly (d, l-lactide-co-glycolide)(PLGA) nanoparticles
(NPs), prepared by nanoprecipitation, carrying rifampicin (RIF) against planktonic, sessile …

Poly(d-amino acid) Nanoparticles Target Staphylococcal Growth and Biofilm Disassembly by Interfering with Peptidoglycan Synthesis

W Feng, M Chittò, W Xie, Q Ren, F Liu, X Kang… - ACS …, 2024 - ACS Publications
d-Amino acids are signals for biofilm disassembly. However, unexpected metabolic
pathways severely attenuate the utilization of d-amino acids in biofilm disassembly, resulting …

Enhanced clearing of wound-related pathogenic bacterial biofilms using protease-functionalized antibiotic nanocarriers

PJ Weldrick, MJ Hardman… - ACS applied materials & …, 2019 - ACS Publications
Biofilms are prevalent in chronic wounds and once formed are very hard to remove, which is
associated with poor outcomes and high mortality rates. Biofilms are comprised of surface …