Steroid concentrations within tissues are modulated by intracellular enzymes. Such “steroid
intracrinology” influences hormone-dependent cancers and obesity and provides targets for …

Abstract 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1; EC 1.1. 1.146) generates active
glucocorticoid hormones. Small molecule inhibitors have been developed to target 11β …

Visualizing tissue distribution of steroid hormones is a promising application of MALDI mass
spectrometry imaging (MSI). On-tissue chemical derivatization using Girard's T reagent has …

Identifying and mapping steroids in tissues can provide opportunities for biomarker
discovery, the interrogation of disease progression, and new therapeutics. Although …

Abnormalities of steroid biosynthesis and excretion are responsible for the development and
prevention of endocrine disorders, such as metabolic syndromes, cancers, and …

Desorption electrospray ionization mass spectrometry (DESI-MS) has been successfully
used to discriminate between normal and cancerous human tissue from different anatomical …

Androgens are essential for male development and reproductive function. They are
transported to their site of action as blood-borne endocrine hormones but can also be …

Abstract 11β-Hydroxysteroid dehydrogenase (11βHSD) is an enzyme complex responsible
for the conversion of hormonally active cortisol to inactive cortisone; two isoforms of the …

Abstract 11β-hydroxysteroid dehydrogenases (11β-HSDs) catalyze the interconversion of
active glucocorticoids (cortisol, corticosterone) and inert 11-keto forms (cortisone, 11 …

In the adrenal gland, neuroendocrine cells that synthesize catecholamines and epithelial
cells that produce steroid hormones are united beneath a common organ capsule to function …