Endocytosis, intracellular traffic and fate of cell penetrating peptide based conjugates and nanoparticles
The insides of cells can be viewed as a treasure trove of targets for therapeutic intervention
of diseases or as deposits for contrasting agents. Increasingly the molecules that need to be …
of diseases or as deposits for contrasting agents. Increasingly the molecules that need to be …
On the biomedical promise of cell penetrating peptides: limits versus prospects
C Foerg, HP Merkle - Journal of pharmaceutical sciences, 2008 - Elsevier
The cell membrane poses a substantial hurdle to the use of pharmacologically active
biomacromolecules that are not per se actively translocated into cells. An appealing …
biomacromolecules that are not per se actively translocated into cells. An appealing …
[HTML][HTML] Cell penetrating peptides in the delivery of biopharmaceuticals
WLL Munyendo, H Lv, H Benza-Ingoula, LD Baraza… - Biomolecules, 2012 - mdpi.com
The cell membrane is a highly selective barrier. This limits the cellular uptake of molecules
including DNA, oligonucleotides, peptides and proteins used as therapeutic agents …
including DNA, oligonucleotides, peptides and proteins used as therapeutic agents …
Cell-penetrating peptides for drug delivery across membrane barriers
C Foged, HM Nielsen - Expert opinion on drug delivery, 2008 - Taylor & Francis
During the last decade, cell-penetrating peptides have been investigated for their ability to
overcome the plasma membrane barrier of mammalian cells for the intracellular or …
overcome the plasma membrane barrier of mammalian cells for the intracellular or …
Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives
Cell penetrating peptides, generally categorized as amphipathic or cationic depending on
their sequence, are increasingly drawing attention as a non-invasive delivery technology for …
their sequence, are increasingly drawing attention as a non-invasive delivery technology for …
Cell-penetrating peptides: mechanism and kinetics of cargo delivery
M Zorko, Ü Langel - Advanced drug delivery reviews, 2005 - Elsevier
Cell-penetrating peptides (CPPs) are short peptides of less than 30 amino acids that are
able to penetrate cell membranes and translocate different cargoes into cells. The only …
able to penetrate cell membranes and translocate different cargoes into cells. The only …
Cell penetrating peptides and the mechanisms for intracellular entry
YS Choi, AE David - Current pharmaceutical biotechnology, 2014 - ingentaconnect.com
A major thrust in the biomedical and pharmaceutical industries is to develop diagnostic and
therapeutic tools that have significantly improved selectivity and specificity compared to the …
therapeutic tools that have significantly improved selectivity and specificity compared to the …
1988–2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research
In 1988, two unrelated papers reported the discovery of peptide vectors with innate cell
translocation properties, setting the ground for a new area of research that over the years …
translocation properties, setting the ground for a new area of research that over the years …
Twenty years of cell‐penetrating peptides: from molecular mechanisms to therapeutics
F Heitz, MC Morris, G Divita - British journal of pharmacology, 2009 - Wiley Online Library
The recent discovery of new potent therapeutic molecules that do not reach the clinic due to
poor delivery and low bioavailability have made of delivery a key stone in therapeutic …
poor delivery and low bioavailability have made of delivery a key stone in therapeutic …
[HTML][HTML] Improving the endosomal escape of cell-penetrating peptides and their cargos: strategies and challenges
A Erazo-Oliveras, N Muthukrishnan, R Baker… - Pharmaceuticals, 2012 - mdpi.com
Cell penetrating peptides (CPPs) can deliver cell-impermeable therapeutic cargos into cells.
In particular, CPP-cargo conjugates tend to accumulate inside cells by endocytosis …
In particular, CPP-cargo conjugates tend to accumulate inside cells by endocytosis …