Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Amyloid plaques and neurofibrillary tangles (NFTs) are the pathological hallmarks of
Alzheimer disease (AD). There is controversy regarding the use of current diagnostic criteria …

There is uncertainty regarding the association of cognitive decline in Alzheimer disease
(AD) with classic histopathologic features-neurofibrillary tangles (NFTs) and" neuritic" …

In order to explore the relationships between the involvement of specific neuronal
populations and cognitive deterioration, and to compare the hierarchical patterns of cortical …

The relationship between progressive cognitive decline and underlying neuropathology
associated with Alzheimer s disease (AD) is a key issue in defining the mechanisms …

Individuals with antemortem preservation of cognition who show autopsy evidence of at
least moderate Alzheimer disease (AD) pathology suggest the possibility of brain reserve …

To test the hypothesis that Alzheimer disease (AD) is a clinical and pathologic continuum
between normal aging and end-stage dementia, we selected a convenience sample of …

Two subtypes of Alzheimer's disease (AD) have been commonly identified: early-and late-
onset forms. Previous studies suggest that early-onset AD patients have more neuritic …

To establish correlations among cognitive states and neuropathology, we have examined 22
subjects (69–97 years of age) from the Baltimore Longitudinal Study of Aging (BLSA), of …

OBJECTIVE: To determine the frequency and possible cognitive effect of histological
Alzheimer's disease (AD) in autopsied older nondemented individuals. DESIGN: Senile …