Accumulation of mesangial matrix in diabetic nephropathy is caused by increased synthesis
and decreased degradation. We have previously demonstrated that incubation in high …

Role of angiotensin II in diabetic nephropathy. Considerable evidence suggests that the
intrarenal renin-angiotensin system plays an important role in diabetic nephropathy …

Diabetic nephropathy (DN) is characterized by accumulation of extracellular matrix (ECM) in
the kidney. Glomerular mesangial expansion and tubulo-interstitial fibrosis eventually leads …

High glucose causes increased matrix synthesis by glomerular mesangial cells and
angiotensin II (Ang II) has been shown to mediate this effect of glucose. These studies …

Aims. Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor-1 (AT-1)
antagonists are used in the treatment of proteinuria of diabetic nephropathy. One of the …

Studies using either angiotensin-converting enzyme inhibitors or type 1 (AT 1) angiotensin II
(ANG II)-receptor blockers indicate that ANG II is a mediator of progressive injury in diabetic …

Diabetic nephropathy, a major cause of morbidity and mortality in patients with diabetes
mellitus, is characterized by the progressive expansion of mesangial matrix that ultimately …

The role of angiotensin-converting enzyme (ACE) inhibition with ramipril on mesenteric
vascular hypertrophy and urinary albumin excretion was explored in a normotensive model …

Previous studies have shown that glucose increases angiotensin II (AngII) levels in rat
glomerular mesangial cells and that AngII mediates the inhibitory effects of high glucose on …