STAT4 Play A Critical Role in Aging and High Fat Diet‐Associated Decline in Long‐Term, Activity‐Dependent Potentiation of Synaptic Transmission
PK Stanton, JL Nadler, X Zhang, C Hollander… - The FASEB …, 2022 - Wiley Online Library
Aging and Alzheimer's disease (AD) both exhibit declines in the magnitude of long‐term,
activity‐dependent synaptic potentiation in humans and animals that correlate with declines …
activity‐dependent synaptic potentiation in humans and animals that correlate with declines …
[HTML][HTML] Myeloid cell deficiency of the inflammatory transcription factor Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet
X Zhang, CM Hollander, MY Khan, M D'silva… - Communications …, 2023 - nature.com
Neuroinflammation is associated with neurodegenerative diseases, including Alzheimer's
and Parkinson's. The cytokine interleukin-12 activates signal transducer and activator of …
and Parkinson's. The cytokine interleukin-12 activates signal transducer and activator of …
STAT3 inhibition reverses neuroinflammation and Aβ metabolism induced by systemic inflammation: molecular and cell biology/neuroinflammation
Background STAT3 is a transcriptional factor involved in various physiological processes,
including immune reaction. Abnormal activation of the, STAT3, has been recently associated …
including immune reaction. Abnormal activation of the, STAT3, has been recently associated …
[HTML][HTML] Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease
M Choi, H Kim, EJ Yang, HS Kim - Journal of pharmacological sciences, 2020 - Elsevier
The pathophysiological roles of astrocytes in the reactive state are thought to have important
significance in the pathogenesis of neurodegenerative diseases, including Alzheimer's …
significance in the pathogenesis of neurodegenerative diseases, including Alzheimer's …
Brain STAT5 signaling modulates learning and memory formation
IC Furigo, HM Melo, NM Lyra e Silva… - Brain Structure and …, 2018 - Springer
The signal transducer and activator of transcription 5 (STAT5) is a transcription factor
recruited by numerous cytokines. STAT5 is important for several physiological functions …
recruited by numerous cytokines. STAT5 is important for several physiological functions …
[HTML][HTML] Inhibiting RIP1 Improves Chronic Stress-Induced Cognitive Impairments in D-Galactose-Induced Aging Mice
W Qing, F Li, X Wang, C Quan, W Ouyang… - Frontiers in behavioral …, 2018 - frontiersin.org
Mounting evidence shows that chronic stress can affect both the structure and function of the
brain resulting in decreased synaptic plasticity and cognitive dysfunction. Although several …
brain resulting in decreased synaptic plasticity and cognitive dysfunction. Although several …
[HTML][HTML] Short-term high-fat diet consumption impairs synaptic plasticity in the aged hippocampus via IL-1 signaling
BM González Olmo, MN Bettes, JW DeMarsh… - npj Science of …, 2023 - nature.com
More Americans are consuming diets higher in saturated fats and refined sugars than ever
before. These trends could have serious consequences for the older population because …
before. These trends could have serious consequences for the older population because …
[HTML][HTML] Short-term high-fat diet consumption impairs synaptic plasticity in the aged hippocampus via IL-1 signaling
BMG Olmo, MN Bettes, JW DeMarsh, F Zhao… - NPJ Science of …, 2023 - ncbi.nlm.nih.gov
More Americans are consuming diets higher in saturated fats and refined sugars than ever
before. These trends could have serious consequences for the older population because …
before. These trends could have serious consequences for the older population because …
[HTML][HTML] STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of Aβ
WL Hsu, YL Ma, DY Hsieh, YC Liu… - …, 2014 - nature.com
Signal transducer and activator of transcription-1 (STAT1) has an important role in
inflammation and the innate immune response, but its role in the central nervous system is …
inflammation and the innate immune response, but its role in the central nervous system is …
[HTML][HTML] Plcg2M28L interacts with high fat/high sugar diet to accelerate Alzheimer's disease-relevant phenotypes in mice
Obesity is recognized as a significant risk factor for Alzheimer's disease (AD). Studies have
supported the notion that obesity accelerates AD-related pathophysiology in mouse models …
supported the notion that obesity accelerates AD-related pathophysiology in mouse models …