Effects of in vivo injury on the neuromuscular junction in healthy and dystrophic muscles
Key points• Strength loss induced by lengthening contractions is typically attributed to
damaged force‐bearing structures within skeletal muscle. Muscle lacking the structural …
damaged force‐bearing structures within skeletal muscle. Muscle lacking the structural …
Recovery of altered neuromuscular junction morphology and muscle function in mdx mice after injury
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which
weakness, increased susceptibility to muscle injury, and inadequate repair underlie the …
weakness, increased susceptibility to muscle injury, and inadequate repair underlie the …
Alterations of neuromuscular junctions in Duchenne muscular dystrophy
RM Lovering, SR Iyer, B Edwards, KE Davies - Neuroscience letters, 2020 - Elsevier
The focus of this review is on Duchenne muscular dystrophy (DMD), which is caused by the
absence of the protein dystrophin and is characterized as a neuromuscular disease in which …
absence of the protein dystrophin and is characterized as a neuromuscular disease in which …
Pre-and postsynaptic changes in the neuromuscular junction in dystrophic mice
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which
weakness, increased susceptibility to muscle injury, and inadequate repair appear to …
weakness, increased susceptibility to muscle injury, and inadequate repair appear to …
Dystrophin-deficient mdx muscle fibers are preferentially vulnerable to necrosis induced by experimental lengthening contractions
B Weller, G Karpati, S Carpenter - Journal of the neurological sciences, 1990 - Elsevier
Lengthening contractions were induced in the right anterior tibialis muscles (ATM) of
anaesthetized normal andmdx (dystrophic) mice by supramaximal, nonfatiguing stimulation …
anaesthetized normal andmdx (dystrophic) mice by supramaximal, nonfatiguing stimulation …
Cycles of myofiber degeneration and regeneration lead to remodeling of the neuromuscular junction in two mammalian models of Duchenne muscular dystrophy
SG Haddix, YI Lee, JN Kornegay, WJ Thompson - PLoS One, 2018 - journals.plos.org
Mice lacking the sarcolemmal protein dystrophin, designated mdx, have been widely used
as a model of Duchenne muscular dystrophy. Dystrophic mdx mice as they mature develop …
as a model of Duchenne muscular dystrophy. Dystrophic mdx mice as they mature develop …
The passive mechanical properties of the extensor digitorum longus muscle are compromised in 2-to 20-mo-old mdx mice
Muscle rigidity and myotendinous junction (MTJ) deficiency contribute to immobilization in
Duchenne muscular dystrophy (DMD), a lethal disease caused by the absence of …
Duchenne muscular dystrophy (DMD), a lethal disease caused by the absence of …
Acute failure of action potential conduction in mdx muscle reveals new mechanism of contraction‐induced force loss
Key points• A primary feature of skeletal muscle lacking the protein dystrophin, as occurring
in Duchenne muscular dystrophy, is a hypersensitivity to eccentric contraction‐induced …
in Duchenne muscular dystrophy, is a hypersensitivity to eccentric contraction‐induced …
Dystrophin deficiency is associated with myotendinous junction defects in prenecrotic and fully regenerated skeletal muscle.
DJ Law, JG Tidball - The American journal of pathology, 1993 - ncbi.nlm.nih.gov
The myotendinous junction (MTJ) is the major site of force transmission from myofibrils
across the muscle cell membrane to the extracellular matrix. The MTJ is thus an appropriate …
across the muscle cell membrane to the extracellular matrix. The MTJ is thus an appropriate …
The role of branched fibres in the pathogenesis of Duchenne muscular dystrophy
S Chan, SI Head - Experimental physiology, 2011 - Wiley Online Library
Branched fibres are a well‐documented phenomenon of regenerating skeletal muscle. They
are found in the muscles of boys with Duchenne muscular dystrophy (DMD), a severe …
are found in the muscles of boys with Duchenne muscular dystrophy (DMD), a severe …