[HTML][HTML] Sildenafil–resorcinol cocrystal: XRPD structure and DFT calculations

R Barbas, V Kumar, O Vallcorba, R Prohens… - Crystals, 2020 - mdpi.com
Herein, the X-ray powder diffraction (XRPD) crystal structure of a new Sildenafil cocrystal is
reported, where resorcinol has been used as the coformer. The crystal structure has been …

Crystal structure from laboratory X-ray powder diffraction data, DFT-D calculations, and Hirshfeld surface analysis of (S)-dapoxetine hydrochloride

AJ Dugarte-Dugarte, RA Toro, J van de Streek… - Powder …, 2022 - cambridge.org
The previously unreported crystal structure of (S)-Dapoxetine hydrochloride (DAPHCl), the
only active pharmaceutical ingredient specially developed for the treatment of premature …

Salt and cocrystals of sildenafil with dicarboxylic acids: solubility and pharmacokinetic advantage of the glutarate salt

P Sanphui, S Tothadi, S Ganguly… - Molecular …, 2013 - ACS Publications
Sildenafil is a drug used to treat erectile dysfunction and pulmonary arterial hypertension.
Because of poor aqueous solubility of the drug, the citrate salt, with improved solubility and …

[HTML][HTML] The solid state landscape of the sildenafil drug

R Barbas, A Llinas, R Prohens - Journal of Pharmaceutical Sciences, 2022 - Elsevier
Sildenafil, the active ingredient of the drug developed by Pfizer for the treatment of erectile
dysfunction was firstly synthesized in 1989 in the United Kingdom and since then it has …

Combined virtual/experimental multicomponent solid forms screening of sildenafil: New salts, cocrystals, and hybrid salt–cocrystals

R Barbas, M Font-Bardia, A Paradkar… - Crystal Growth & …, 2018 - ACS Publications
New multicomponent solid forms of sildenafil have been discovered by means of a
combined virtual/experimental cocrystal screening. Coformer selection of candidates was …

Molecular and crystal structure of sildenafil base

D Stepanovs, A Mishnev - Zeitschrift für Naturforschung B, 2012 - degruyter.com
Sildenafil citrate monohydrate, well known as Viagra®, is a drug for the treatment of erectile
dysfunction. Here we present the X-ray crystal structure of the sildenafil base …

Synthesis, powder diffraction pattern, crystal structure determination of the pharmaceutical co-crystal of levetiracetam and 3, 5-dinitrosalicylic acid

L Shi, Z Chen, H Kafafy, Z Zhang, G Zhu, J Yao… - Powder …, 2023 - cambridge.org
(S)-α-Ethyl-2-oxo-1-pyrrolidineacetamide (trade name levetiracetam), a derivative of
piracetam, is used clinically as an add-on treatment for partial-onset seizures. In this study …

[HTML][HTML] Why sildenafil and sildenafil citrate monohydrate crystals are not stable?

S Sawatdee, C Pakawatchai, K Nitichai… - Saudi Pharmaceutical …, 2015 - Elsevier
Sildenafil citrate was crystallized by various techniques aiming to determine the behavior
and factors affecting the crystal growth. There are only 2 types of sildenafil obtaining from …

[HTML][HTML] Two novel co-crystals of naproxen: comparison of stability, solubility and intermolecular interaction

C Xing, T Chen, L Wang, Q An, Y Jin, D Yang, L Zhang… - Pharmaceuticals, 2022 - mdpi.com
Two novel co-crystals of naproxen (NPX) were designed and prepared at a stoichiometric
ratio of 1: 1, namely, naproxen–caprolactam (NPX–CPL) and naproxen–oxymatrine (NPX …

[HTML][HTML] DFT–Assisted Structure Determination from Powder X-ray Diffraction Data of a New Zonisamide/ϵ-Caprolactam Cocrystal

R Barbas, A Portell, R Prohens, A Frontera - Crystals, 2022 - mdpi.com
The crystal structure of a new zonisamide cocrystal, an anticonvulsant drug used to treat the
symptoms of epilepsy and Parkinson's disease, with ϵ-caprolactam is reported herein. The …