Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in
the formation of multiple membrane-less organelles involved in RNA metabolism, including …

Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a …

A common feature of non‐coding repeat expansion disorders is the accumulation of RNA
repeats as RNA foci in the nucleus and/or cytoplasm of affected cells. These RNA foci can …

Hexanucleotide repeat expansion in C9orf72 is the most common pathogenic mutation in
patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration …

Highlights•Massive GGGGCC repeat expansion in C9orf72 is the most common cause of
ALS/FTD.•Repeat RNA sequesters RNA-binding proteins and inhibits nucleocytoplasmic …

Aberrant hexanucleotide repeat expansions in C9orf72 are the most common genetic
change underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) …

Introduction The most common forms of amyotrophic lateral sclerosis and frontotemporal
dementia are caused by a large GGGGCC repeat expansion in the first intron of the C9orf72 …

Hexanucleotide repeat expansions in the C9ORF72 gene are causally associated with
frontotemporal lobar dementia (FTLD) and/or amyotrophic lateral sclerosis (ALS). The …

Membraneless RNA granules originate via phase separation events driven by multivalent
interactions. As RNA is the defining component of such granules, we examined how RNA …

Expansion of a hexanucleotide (GGGGCC) repeat in the gene chromosome 9 open reading
frame 72 (C9ORF72) is the most common cause of amyotrophic lateral sclerosis and …