Our group assays natural products that are less toxic and more effective than available
nitroheterocycles as promising therapeutic options for patients with Chagas disease. Our …

Because of its severe side effects and variable efficacy, the current treatment for Chagas
disease is unsatisfactory. Natural compounds are good alternative chemotherapeutic agents …

Background Deoxymikanolide is a sesquiterpene lactone isolated from Mikania micrantha
and M. variifolia which, has previously demonstrated in vitro activity on Trypanosoma cruzi …

Abstract Background: The sesquiterpene lactones (STLs) eupatoriopicrin (EP) and estafietin
(ES), isolated from Stevia alpina Griseb.(Asteraceae) and Stevia maimarensis (Hieron.) …

Eupomatenoid-5, a compound isolated from leaves of Piper regnellii var. pallescens,
showed antiprotozoal activity against the epimastigote proliferative stages and intracellular …

Chagas disease is a neglected tropical disease, caused by the protozoan parasite
Trypanosoma cruzi, which affects more than eight million people in Tropical and Subtropical …

Despite ongoing efforts, the available treatments for Chagas' disease are still unsatisfactory,
especially in the chronic phase of the disease. Our previous study reported the strong …

Aims From well-delimited immunomodulatory, redox and antimicrobial properties;
metronidazole and eugenol were used as structural platforms to assembly two new …

Chagas disease is caused by the hemoflagellate protozoa Trypanosoma cruzi and is one of
the most important neglected tropical diseases, especially in Latin American countries …

Background From a previous screening of Brazilian biodiversity for antiprotozoal activity, the
hexane extract from leaves of Nectandra leucantha (Nees & Mart.)(Lauraceae) …