The effects of the histone deacetylase inhibitors (HDACi) trichostatin A (TSA) and sodium
butyrate (NaBt) were studied in A549, HT29 and FHC human cell lines. Global histone …

It is well established that modification of lysines in histone molecules correlates with gene
expression and chromatin structure. It is not known whether this operates entirely at a local …

Antibodies specific for acetylated isoforms of histone H4 have been used to compare
acetylation of this histone in interphase and metaphase cells. Two rabbit antisera (R5 and …

We investigated the relationship between linker histone stoichiometry and the acetylation of
core histones in vivo. Exponentially growing cell lines induced to overproduce either of two …

The application of reversed-phase high-pressure liquid chromatography under gradient
conditions and electrospray ion trap mass spectrometry (LC–ESI–MS) to the analysis of …

Histone acetylation is emerging as a major regulatory mechanism thought to modulate gene
expression by altering the accessibility of transcription factors to DNA. In this study, treatment …

In this study we show a striking correlation between histone H10 gene expression and
histone acetylation. Trichostatin A, a highly specific inhibitor of histone deacetylase …

Recently a model for eukaryotic transcriptional activation has been proposed in which
histone hyperacetylation causes release of nucleosomal supercoils, and this unconstrained …

This paper describes an integrated approach that couples stable isotope labeling with
amino acids in cell culture to acetic acid-urea polyacrylamide gel electrophoresis (AU …

Alterations in the chromatin structure are preferentially involved in the regulation of cell
functions, including gene expression, in eukaryotes. Three types of mechanisms, by which …