Excessive accumulation of the extracellular matrix proteins primarily produced by activated
hepatic stellate cells (HSC) leads to liver fibrosis. To date, no successful therapeutic …

Interferon gamma (IFNγ) is a potent cytokine that displays a variety of anti-viral, anti-
proliferative, immunomodulatory, apoptotic and anti-fibrotic functions. However, its clinical …

Targeting hepatic stellate cells (HSCs) has been challenging due to the lack of specific
receptors or motifs on the cells. The aim of the present study was to develop a HSC-specific …

Regardless of its cause, liver fibrosis is characterized by the excessive accumulation of
extracellular matrix (ECM) in the liver. Hepatic stellate cells (HSCs) are the main producers …

Hepatic stellate cells play a crucial role in the pathogenesis of hepatic fibrosis. Thus,
pharmacological inhibition of pro-fibrotic activities of these cells might lead to an effective …

Liver fibrogenesis is associated with excessive production of extracellular matrix by
myofibroblasts that often leads to cirrhosis and consequently liver dysfunction and death …

Liver fibrogenesis is a process tightly controlled by endogenous anti‐and pro‐fibrogenic
factors. Interferon gamma (IFNγ) is a potent antifibrogenic cytokine in vitro and might …

Liver diseases are a leading cause of death worldwide and are rising exponentially due to
increasing prevalence of metabolic disorders. Hepatic stellate cells (HSCs) are recognized …

No drugs have been approved clinically for the therapy of hepatic fibrosis. Though interferon-
γ (IFN-γ) is a highly effective anti-fibrotic agent in vitro and in some animal models in vivo, its …

No satisfactory anti-fibrotic therapies have yet been applied clinically. One of the main
reasons is the inability to specifically target the responsible cells to produce an available …