Inhibition of intracellular triglyceride lipolysis suppresses cold-induced brown adipose tissue metabolism and increases shivering in humans

DP Blondin, F Frisch, S Phoenix, B Guérin, ÉE Turcotte… - Cell metabolism, 2017 - cell.com
Indirect evidence from human studies suggests that brown adipose tissue (BAT)
thermogenesis is fueled predominantly by fatty acids hydrolyzed from intracellular …

Lipid droplets in brown adipose tissue are dispensable for cold-induced thermogenesis

C Chitraju, AW Fischer, RV Farese, TC Walther - Cell reports, 2020 - cell.com
Brown adipocytes store metabolic energy as triglycerides (TGs) in lipid droplets (LDs). Fatty
acids released from brown adipocyte LDs by lipolysis are thought to activate and fuel UCP1 …

In vivo measurement of energy substrate contribution to cold‐induced brown adipose tissue thermogenesis

SM Labbé, A Caron, I Bakan, M Laplante… - The FASEB …, 2015 - Wiley Online Library
The present study was designed to investigate the effects of cold on brown adipose tissue
(BAT) energy substrate utilization in vivo using the positron emission tomography tracers …

Lipolysis in brown adipocytes is not essential for cold-induced thermogenesis in mice

H Shin, Y Ma, T Chanturiya, Q Cao, Y Wang… - Cell metabolism, 2017 - cell.com
Lipid droplet (LD) lipolysis in brown adipose tissue (BAT) is generally considered to be
required for cold-induced nonshivering thermogenesis. Here, we show that mice lacking …

Substantial metabolic activity of human brown adipose tissue during warm conditions and cold-induced lipolysis of local triglycerides

G Weir, LE Ramage, M Akyol, JK Rhodes, CJ Kyle… - Cell metabolism, 2018 - cell.com
Current understanding of in vivo human brown adipose tissue (BAT) physiology is limited by
a reliance on positron emission tomography (PET)/computed tomography (CT) scanning …

Human brown adipose tissue as a target for obesity management; beyond cold‐induced thermogenesis

RKC Loh, BA Kingwell, AL Carey - Obesity reviews, 2017 - Wiley Online Library
Elevating energy expenditure via adaptive thermogenesis in brown adipose tissue (BAT) is
a potential strategy to reverse obesity. Much early enthusiasm for this approach, based on …

Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice

S Lim, J Honek, Y Xue, T Seki, Z Cao, P Andersson… - Nature protocols, 2012 - nature.com
Exposure of humans and rodents to cold activates thermogenic activity in brown adipose
tissue (BAT). This protocol describes a mouse model to study the activation of BAT and …

[HTML][HTML] Postprandial oxidative metabolism of human brown fat indicates thermogenesis

MU Din, T Saari, J Raiko, N Kudomi, SF Maurer… - Cell metabolism, 2018 - cell.com
Human studies suggest that a meal elevates glucose uptake in brown adipose tissue (BAT).
However, in postprandial state the thermogenic activity and the metabolism of non-esterified …

Increased brown adipose tissue oxidative capacity in cold-acclimated humans

DP Blondin, SM Labbé, HC Tingelstad… - The Journal of …, 2014 - academic.oup.com
Context: Recent studies examining brown adipose tissue (BAT) metabolism in adult humans
have provided convincing evidence of its thermogenic potential and role in clearing …

Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans

M Chondronikola, E Volpi, E Børsheim, C Porter… - Cell metabolism, 2016 - cell.com
Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose
metabolism in humans. However, the physiological significance of human BAT in lipid …