Inhibition of intracellular triglyceride lipolysis suppresses cold-induced brown adipose tissue metabolism and increases shivering in humans
DP Blondin, F Frisch, S Phoenix, B Guérin, ÉE Turcotte… - Cell metabolism, 2017 - cell.com
Indirect evidence from human studies suggests that brown adipose tissue (BAT)
thermogenesis is fueled predominantly by fatty acids hydrolyzed from intracellular …
thermogenesis is fueled predominantly by fatty acids hydrolyzed from intracellular …
Lipid droplets in brown adipose tissue are dispensable for cold-induced thermogenesis
Brown adipocytes store metabolic energy as triglycerides (TGs) in lipid droplets (LDs). Fatty
acids released from brown adipocyte LDs by lipolysis are thought to activate and fuel UCP1 …
acids released from brown adipocyte LDs by lipolysis are thought to activate and fuel UCP1 …
In vivo measurement of energy substrate contribution to cold‐induced brown adipose tissue thermogenesis
The present study was designed to investigate the effects of cold on brown adipose tissue
(BAT) energy substrate utilization in vivo using the positron emission tomography tracers …
(BAT) energy substrate utilization in vivo using the positron emission tomography tracers …
Lipolysis in brown adipocytes is not essential for cold-induced thermogenesis in mice
H Shin, Y Ma, T Chanturiya, Q Cao, Y Wang… - Cell metabolism, 2017 - cell.com
Lipid droplet (LD) lipolysis in brown adipose tissue (BAT) is generally considered to be
required for cold-induced nonshivering thermogenesis. Here, we show that mice lacking …
required for cold-induced nonshivering thermogenesis. Here, we show that mice lacking …
Substantial metabolic activity of human brown adipose tissue during warm conditions and cold-induced lipolysis of local triglycerides
G Weir, LE Ramage, M Akyol, JK Rhodes, CJ Kyle… - Cell metabolism, 2018 - cell.com
Current understanding of in vivo human brown adipose tissue (BAT) physiology is limited by
a reliance on positron emission tomography (PET)/computed tomography (CT) scanning …
a reliance on positron emission tomography (PET)/computed tomography (CT) scanning …
Human brown adipose tissue as a target for obesity management; beyond cold‐induced thermogenesis
RKC Loh, BA Kingwell, AL Carey - Obesity reviews, 2017 - Wiley Online Library
Elevating energy expenditure via adaptive thermogenesis in brown adipose tissue (BAT) is
a potential strategy to reverse obesity. Much early enthusiasm for this approach, based on …
a potential strategy to reverse obesity. Much early enthusiasm for this approach, based on …
Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice
S Lim, J Honek, Y Xue, T Seki, Z Cao, P Andersson… - Nature protocols, 2012 - nature.com
Exposure of humans and rodents to cold activates thermogenic activity in brown adipose
tissue (BAT). This protocol describes a mouse model to study the activation of BAT and …
tissue (BAT). This protocol describes a mouse model to study the activation of BAT and …
[HTML][HTML] Postprandial oxidative metabolism of human brown fat indicates thermogenesis
Human studies suggest that a meal elevates glucose uptake in brown adipose tissue (BAT).
However, in postprandial state the thermogenic activity and the metabolism of non-esterified …
However, in postprandial state the thermogenic activity and the metabolism of non-esterified …
Increased brown adipose tissue oxidative capacity in cold-acclimated humans
Context: Recent studies examining brown adipose tissue (BAT) metabolism in adult humans
have provided convincing evidence of its thermogenic potential and role in clearing …
have provided convincing evidence of its thermogenic potential and role in clearing …
Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans
Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose
metabolism in humans. However, the physiological significance of human BAT in lipid …
metabolism in humans. However, the physiological significance of human BAT in lipid …