Inflammasome signaling affects anxiety-and depressive-like behavior and gut microbiome composition

ML Wong, A Inserra, MD Lewis, CA Mastronardi… - Molecular …, 2016 - nature.com
The inflammasome is hypothesized to be a key mediator of the response to physiological
and psychological stressors, and its dysregulation may be implicated in major depressive …

Fecal microbiota transplantation ameliorates stress-induced depression-like behaviors associated with the inhibition of glial and NLRP3 inflammasome in rat brain

J Rao, Y Qiao, R Xie, L Lin, J Jiang, C Wang… - Journal of Psychiatric …, 2021 - Elsevier
Background Evidence from previous studies has demonstrated that the gut-microbiota-brain
axis is vital in regulating of behavior and neuroinflammation in the central nervous system …

Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2

Y Zhang, R Huang, M Cheng, L Wang, J Chao, J Li… - Microbiome, 2019 - Springer
Background Inflammasomes have been found to interact with the gut microbiota, and this
effect is associated with depression, but the mechanisms underlying this interaction have not …

Gut microbiota are associated with psychological stress-induced defections in intestinal and blood–brain barriers

S Geng, L Yang, F Cheng, Z Zhang, J Li, W Liu… - Frontiers in …, 2020 - frontiersin.org
Altered gut microbiota has been identified during psychological stress, which causes severe
health issues worldwide. The integrity of the intestinal barrier and blood–brain barrier …

Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression- and anhedonia-like phenotypes in antibiotic-treated mice via the vagus nerve

S Wang, T Ishima, J Zhang, Y Qu, L Chang… - Journal of …, 2020 - Springer
Background The brain–gut–microbiota axis plays a role in the pathogenesis of stress-related
disorders such as depression. In this study, we examined the effects of fecal microbiota …

The role of inflammation and the gut microbiome in depression and anxiety

JM Peirce, K Alviña - Journal of neuroscience research, 2019 - Wiley Online Library
The study of the gut microbiome has increasingly revealed an important role in modulating
brain function and mental health. In this review, we underscore specific pathways and …

The gut microbiome modulates the changes in liver metabolism and in inflammatory processes in the brain of chronic unpredictable mild stress rats

W Lv, X Wu, W Chen, Y Li, G Zhang… - Oxidative Medicine …, 2019 - Wiley Online Library
Generally, depression is the result of complex gene‐environment interactions. Recent
studies have showed that the gut microbiota can affect brain function through the microbiota …

Xiaoyaosan improves antibiotic-induced depressive-like and anxiety-like behavior in mice through modulating the gut microbiota and regulating the NLRP3 …

W Hao, J Wu, N Yuan, L Gong, J Huang… - Frontiers in …, 2021 - frontiersin.org
Disturbance of the gut microbiota plays an essential role in mental disorders such as
depression and anxiety. Xiaoyaosan, a traditional Chinese medicine formula, has a wide …

The inflammasome: pathways linking psychological stress, depression, and systemic illnesses

M Iwata, KT Ota, RS Duman - Brain, behavior, and immunity, 2013 - Elsevier
Stress is a common occurrence in everyday life and repeated or traumatic stress can be a
precipitating factor for illnesses of the central nervous system, as well as peripheral organ …

NLRP3 inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation

Y Zhang, L Liu, YZ Liu, XL Shen, TY Wu… - International Journal …, 2015 - academic.oup.com
Background: Evidence from both clinical and experimental research indicates that the
immune-brain interaction plays a pivotal role in the pathophysiology of depression. A multi …