Sperm and oocytes are terminally differentiated, sex-specific germ cells, which, upon
fertilization will generate a new embryo and leads to species propagation by sexual …

Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early
embryos, plays a crucial role in regulating genome functions at critical stages of …

Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early
embryos, plays a crucial role in regulating genome functions at critical stages of …

Primordial germ cells (PGCs) undergo dramatic rearrangements to their methylome during
embryogenesis, including initial genome-wide DNA demethylation that establishes the …

Primordial germ cells (PGCs), the precursors of sperm and eggs, are the route to totipotency
and require establishment of a unique epigenome in this lineage. The genetic program for …

Primordial germ cells (PGCs) are the cellular precursors for mature gametes which are
responsible for giving rise to embryonic development and the next generation of PGCs …

Primordial germ cell (PGC) development is characterized by global epigenetic remodeling,
which resets genomic potential and establishes an epigenetic ground state. Here we …

Primordial germ cells (PGCs) are undifferentiated germ line cells in embryos that emerge at
early stages of embryonic development, and then differentiate into eggs or sperm in gonads …

Preimplantation embryos and primordial germ cells undergo extensive global
reprogramming of the DNA methylation pattern, which is a bearer of all crucial regulatory …

Epigenetic reprogramming is a central process during mammalian germline development.
Genome-wide DNA demethylation in primordial germ cells (PGCs) is a prerequisite for the …