The long-term stability of implanted micromachined neural probes is compromised due to
the glial scar formation at the insertion site. In this study, we developed a novel nitrocellulose …

We present the development, characterization and in vivo validation of a novel drug eluting
coating that has been applied to flexible neural probes. The coating consists of drug eluting …

Glial scar formation around implanted silicon neural probes compromises their ability to
facilitate long-term recordings. One approach to modulate the tissue reaction around …

The performance of neural electrodes implanted in the brain is often limited by host
response in the surrounding brain tissue, including astrocytic scar formation, neuronal cell …

Stable interconnection to neurons in vivo over long time-periods is critical for the success of
future advanced neuroelectronic applications. The inevitable foreign body reaction towards …

Microfabricated neural prosthetic devices hold great potential for increasing knowledge of
brain function and treating patients with lost CNS function. Time-dependent loss of brain …

Si-multi-electrode arrays implanted into brain tissue for long-term recording lose electrical
connectivity due to the post-implantation inflammatory reaction. This inflammatory reaction …

Soft, cell integrated electrode coatings are proposed to address the problem of scar tissue
encapsulation of stimulating neuroprosthetics. The aim of these studies was to prove the …

Controlled release coatings were developed for neuroprostheses with the aim of combating
the tissue reaction following implantation in the brain. The coatings consist of poly …

Chronic recordings from micromachined neural electrode arrays often fail a few weeks after
implantation primarily due to the formation of an astro-glial sheath around the implant. We …