Increased serum levels of uric acid have been associated with the onset and development of
chronic kidney disease (CKD), cardiovascular disease, and mortality, through several …

Hyperuricemia is known to be associated with the presence of cardiovascular and metabolic
syndrome and with the development of incipient kidney disease and an accelerated renal …

Background: The connection between uric acid (UA) and renal impairment is well known
due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging …

Uric acid is the final product of purine metabolism in humans. The final two reactions of its
production catalyzing the conversion of hypoxanthine to xanthine and the latter to uric acid …

Uric acid (UA) is a potent endogenous antioxidant. However, high concentrations of this
molecule have been associated with cardiovascular disease (CVD) and renal dysfunction …

The prevalence of chronic kidney disease (CKD) is increasing worldwide. Although
hyperuricemia has been associated with CKD in many studies, it remains controversial …

The expected life span for patients with advanced chronic kidney disease (CKD) is
substantially shorter than that expected for age-, gender-, and race-matched members of the …

In chronic kidney disease inflammatory processes and stimulation of immune cells result in
overproduction of free radicals. In combination with a reduced antioxidant capacity this …

Soluble uric acid has important biologic roles. While it acts as an antioxidant, there is also
evidence that uric acid has pro-inflammatory and proliferative effects on VSMC, and causes …

Post-hoc analyses of the GREACE and the LIFE trials have renewed the interest in elevated
serum uric acid (SUA) as a factor contributing to atherosclerotic cardiovascular disease …