Background Potassium depletion by thiazide diuretics is associated with a rise in blood
glucose. We assessed whether addition or substitution of a potassium-sparing diuretic …

Hypertension guidelines advise limiting the dose of thiazide diuretics and avoiding
combination with β-blockade, because of increased risk of diabetes mellitus. We tested …

National guidelines and a recent clinical trial have supported the use of thiazide diuretics as
the preferred initial pharmacological treatment for hypertension. However, evidence from …

Thiazide diuretics have been recommended as the pre-ferred class of antihypertensive
(AHT) drugs for initial therapy and for inclusion in a regimen of multiple drugs. 1 This …

This study is a meta-analysis of the metabolic profile (fasting plasma glucose and serum
potassium) of low-dose thiazide and thiazide-like diuretics. The meta-analysis involved 10 …

Patients receiving thiazide diuretics have a higher risk of impaired glucose tolerance or even
incident diabetes, but the change of blood glucose level varies across different trials. The …

Background Thiazide diuretics can impair glucose metabolism and increase new-onset
diabetes. Adding an angiotensin receptor blocker to diuretics may protect against these …

Thiazides, recommended as first-line antihypertensive therapy, are associated with an
increased risk of diabetes. Thiazides also lower serum potassium. To determine whether …

Abstract Purpose of Review In patients with prediabetes or type 2 diabetes, the use of
thiazides as antihypertensive agents has been challenged because associated metabolic …

Background In the PATHWAY-2 study of resistant hypertension, spironolactone reduced
blood pressure substantially more than conventional antihypertensive drugs. We did three …