G protein‐coupled receptors (GPCR) exhibit the ability to form receptor complexes that
include molecularly different GPCR (ie, GPCR heteromers), which endow them with singular …

The A2AR is largely coexpressed with D2Rs and enkephalin mRNA in the striatum where it
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …

The dopamine D1 and D2 receptors are major receptors in the regulation of striatal function
and striatal adenosine A1 and A2A receptors are major modulators of their signaling. The …

In Parkinson's disease a degeneration of dopaminergic neurons of the nigrostriatal pathway
is observed. Loss of dopaminergic regulation of striatal neuron activity results in altered …

Prefrontal cortex (PFC) circuits are modulated by dopamine acting on D1‐and D2‐like
receptors, which are pharmacologically exploited to manage neuropsychiatric conditions …

Heteromers of G-protein-coupled receptors (GPCRs) have emerged as potential novel
targets for drug development. Accumulating evidence indicates that GPCRs can form …

Dopamine D2 receptors (Rs) and adenosine A2ARs are coexpressed on striatopallidal
neurons, where they mediate opposing actions. In agreement with the idea that D2Rs …

Adenosine and dopamine (DA) strongly modulate the neuronal activity in the striatum by pre-
and postsynaptic mechanisms. As several behavioral and molecular studies indicate a …

Adenosine A2A-dopamine D2 receptor interactions play a very important role in striatal
function. A2A-D2 receptor interactions provide an example of the capabilities of information …

Emerging evidence shows that G protein-coupled receptors can form homo-and heteromers.
These include adenosine A2A receptor–dopamine D2 receptor heteromers, which are most …