Pulmonary fibrosis is a progressive, dysregulated response to injury culminating in
compromised lung function due to excess extracellular matrix production. The heparan …

Abstract The C‑X‑C Motif Chemokine Receptor 4/C‑X‑C Motif Chemokine Ligand 12
(CXCR4/CXCL12) axis has been implicated in the pathogenesis of pulmonary fibrosis …

Fibrotic interstitial lung diseases are characterized by progressive decline in lung function
and premature death from respiratory failure. Fibrocytes are circulating bone marrow …

Background CXCR4, a transmembrane-receptor located on epithelial cells that is activated
by CXCL12, may have a role in IPF via migration of CXCR4+ fibrocytes to the lung …

Aberrant vascular remodeling is a central hallmark for the development and progression of
idiopathic pulmonary fibrosis. The mechanisms underlying the pathophysiologic alterations …

Lung fibrosis is a progressive and often fatal lung disease characterized by fibroblast
proliferation and excessive deposition of extracellular matrix in the lungs. The chemokine …

CXC chemokine receptor 3 (CXCR3) is the receptor for the IFN-γ–inducible CXC
chemokines MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11. CXCR3 is expressed on …

Given the critical role that endothelial cell dysfunction plays in the pathogenesis of
pulmonary hypertensive diseases, we set out to establish if CXCR7, a receptor for the pro …

Fibrosis is a major cause of mortality worldwide, characterized by myofibroblast activation
and excessive extracellular matrix deposition. Systemic sclerosis is a prototypic fibrotic …

The chemokine CXCL13 controls the normal organization of secondary lymphoid tissues
and the neogenesis of ectopic lymphoid structures in nonlymphoid organs, particularly the …