Autonomous pacemakers are crucial elements in many neural circuits. This is particularly
true for the basal ganglia. This richly interconnected group of nuclei is rife with both fast-and …

Rhythmically active neuronal networks give rise to rhythmic motor activities but also to
seemingly non-rhythmic behaviors such as sleep, arousal, addiction, memory and cognition …

Since the early observations made by Santiago Ramon y Cajal more than a century ago till
now, astrocytes have gradually gained protagonism as essential partners of neurons in …

Dopaminergic neurons of the substantia nigra pars compacta are autonomous pacemakers.
This activity is responsible for the sustained release of dopamine necessary for the proper …

Hippocampal CA1 pyramidal neurons are normally quiescent but can fire spontaneously
when stimulated by muscarinic agonists. In brain slice recordings from mouse CA1 …

Mutually inhibitory pacemaker neurons with duty cycle close to 50% operate as a half-center
oscillator (anti-phase coordination, ie, 180° out of phase), even in the presence of weak to …

We analyzed ionic currents that regulate pacemaking in dopaminergic neurons of the mouse
ventral tegmental area by comparing voltage trajectories during spontaneous firing with …

Electrical coupling between neurons with similar properties is often studied. Nonetheless,
the role of electrical coupling between neurons with widely different intrinsic properties also …

A crucial aspect of pacemaker current (Ih) function is the regulation by cyclic nucleotides. To
assess the endogenous mechanisms controlling cAMP levels in the vicinity of pacemaker …

Neuronal oscillators can function as bistable toggle switches, flipping between quiescence
and rhythmic firing in response to an input stimulus. In theory, such switching should be …