Neuropathic pain is a debilitating clinical problem and difficult to treat. Nerve injury causes a
long-lasting reduction in K+ channel expression in the dorsal root ganglion (DRG), but little …

Nerve injury-induced downregulation of voltage-gated potassium channel subunit Kcna2 in
the dorsal root ganglion (DRG) is critical for DRG neuronal excitability and neuropathic pain …

Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons,
which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses …

Neuropathic pain is a severe health problem for which there is a lack of effective therapy. A
frequent underlying condition of neuropathic pain is a sustained overexcitability of pain …

Expressional changes of pain-associated genes in primary sensory neurons of DRG are
critical for neuropathic pain genesis. DNA methyltransferase (DNMT)-triggered DNA …

Chronic neuropathic pain affects millions of individuals worldwide, is typically long-lasting,
and remains poorly treated with existing therapies. Neuropathic pain arising from peripheral …

Voltage‐gated potassium channels (Kv) are important regulators of neuronal excitability for
its role of regulating resting membrane potential and repolarization. Recent studies show …

Neuropathic pain is a challenging clinical problem and remains difficult to treat. Altered gene
expression in peripheral sensory nerves and neurons due to nerve injury is well …

A-type potassium currents are important determinants of neuronal excitability. In spinal cord
dorsal horn neurons, A-type currents are modulated by extracellular signal-regulated …

Neurotransmitter release from mammalian sensory neurons is controlled by CaV2. 2 N-type
calcium channels. N-type channels are a major target of neurotransmitters and drugs that …