Previous investigations have shown that culture of freshly isolated hepatocytes under
conventional conditions, ie, on dried rat tail collagen in the presence of growth factors …

Rat hepatocytes de-differentiate and proliferate when cultured on collagen-coated dishes in
a chemically defined Hepatocyte Growth Medium in the presence of hepatocyte growth …

As an approach to understanding physiological mechanisms that control the proliferation of
highly differentiated cells, we are addressing whether certain hepatic transcription factors …

The extracellular matrix (ECM) promotes tissue morphogenesis, cell migration, and the
differentiation of a variety of cell types. However, the mechanisms by which ECM causes …

Freshly isolated adult rat hepatocytes, when cultured on type I collagen (commercially
available as Vitrogen), assume a polygonal shape, form a stable monolayer within 24 hours …

During the period of rapid cell growth which follows a two-thirds partial hepatectomy, the
liver is able to compensate for the acute loss of two-thirds of its mass to maintain serum …

Studies were carried out to analyze how different extracellular matrix (ECM) molecules
regulate hepatocyte growth and differentiation. Freshly isolated rat hepatocytes were …

In the present study, we showed the role of the liver‐enriched transcription factors in the
transition during which proliferating hepatocytes become quiescent. We used primary rat …

Hepatocytes in primary culture enter into clonal proliferation in the chemically defined
hepatocyte growth medium in the presence of hepatocyte growth factor and epidermal …

This study was undertaken to determine the importance of integrin binding and cell shape
changes in the control of cell-cycle progression by extracellular matrix (ECM). Primary rat …