Biologicals have transformed the way of treatment of many immune-mediated disorders
including cancer, autoimmune, and allergic diseases.[[1]] Biologicals and the understanding …

The article discusses the historical evolution of asthma treatment and highlights recent
advancements in personalized medicine, specifically the use of biologics in severe asthma …

Objective To review key literature on asthma biologic therapeutics—currently available and
under investigation—to inform a rational approach to select biologics for the management of …

Over the last 4 decades there has been a significant global increase in the incidence and
prevalence of IgE-mediated allergy. Although much progress has been made in the …

The seminal work of Köhler and Milstein, 1 which led to a Nobel Prize in 1984, ushered in a
new era of biologic therapy. In the years since, we have witnessed the development of …

Biologic agents (also termed biologicals or biologics) are therapeutics that are synthesized
by living organisms and directed against a specific determinant, for example, a cytokine or …

abstract Asthma is a heterogeneous disease with considerable variability noted in disease
severity, patterns of airway inflammation, and achievement of disease control on current …

Introduction: The precision medicine approach that is now mandatory for severe asthma
management includes the use of novel biologic agents blocking specific immunological …

Biologic choice in co-eligible patients should be guided by shared decision-making, patient-
related factors and co-morbidities. Again, there is no consensus on which patients and at …

Five biologic medications are approved in the United States for the treatment of asthma that
is not well controlled with other therapies. All target asthma with elevated type 2 …