Genomic basis for RNA alterations revealed by whole-genome analyses of 27 cancer types
We present the most comprehensive catalogue of cancer-associated gene alterations
through characterization of tumor transcriptomes from 1,188 donors of the Pan-Cancer …
through characterization of tumor transcriptomes from 1,188 donors of the Pan-Cancer …
[HTML][HTML] Genomic basis for RNA alterations in cancer
PCAWG Transcriptome Core Group Calabrese Claudia … - Nature, 2020 - nature.com
Transcript alterations often result from somatic changes in cancer genomes. Various forms of
RNA alterations have been described in cancer, including overexpression, altered splicing …
RNA alterations have been described in cancer, including overexpression, altered splicing …
Pan-cancer study of heterogeneous RNA aberrations
Pan-cancer studies have transformed our understanding of recurrent somatic mutations that
contribute to cancer pathogenesisn however, there has yet to be a full investigation of the …
contribute to cancer pathogenesisn however, there has yet to be a full investigation of the …
Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers
B Alaei-Mahabadi, J Bhadury… - Proceedings of the …, 2016 - National Acad Sciences
Tumor genomes are mosaics of somatic structural variants (SVs) that may contribute to the
activation of oncogenes or inactivation of tumor suppressors, for example, by altering gene …
activation of oncogenes or inactivation of tumor suppressors, for example, by altering gene …
Functional genomic analysis of chromosomal aberrations in a compendium of 8000 cancer genomes
TM Kim, R Xi, LJ Luquette, RW Park… - Genome …, 2013 - genome.cshlp.org
A large database of copy number profiles from cancer genomes can facilitate the
identification of recurrent chromosomal alterations that often contain key cancer-related …
identification of recurrent chromosomal alterations that often contain key cancer-related …
Integrative analysis of the melanoma transcriptome
Global studies of transcript structure and abundance in cancer cells enable the systematic
discovery of aberrations that contribute to carcinogenesis, including gene fusions …
discovery of aberrations that contribute to carcinogenesis, including gene fusions …
[HTML][HTML] Allelic imbalance of somatic mutations in cancer genomes and transcriptomes
Somatic mutations in cancer genomes often show allelic imbalance (AI) of mutation
abundance between the genome and transcriptome, but there is not yet a systematic …
abundance between the genome and transcriptome, but there is not yet a systematic …
[HTML][HTML] Comprehensive analysis of the genome transcriptome and proteome landscapes of three tumor cell lines
We here present a comparative genome, transcriptome and functional network analysis of
three human cancer cell lines (A431, U251MG and U2OS), and investigate their relation to …
three human cancer cell lines (A431, U251MG and U2OS), and investigate their relation to …
[HTML][HTML] High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
The impact of somatic structural variants (SVs) on gene expression in cancer is largely
unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes …
unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes …
[HTML][HTML] Systematic pan-cancer analysis of somatic allele frequency
Imbalanced expression of somatic alleles in cancer can suggest functional and selective
features, and can therefore indicate possible driving potential of the underlying genetic …
features, and can therefore indicate possible driving potential of the underlying genetic …