We present the most comprehensive catalogue of cancer-associated gene alterations
through characterization of tumor transcriptomes from 1,188 donors of the Pan-Cancer …

Transcript alterations often result from somatic changes in cancer genomes. Various forms of
RNA alterations have been described in cancer, including overexpression, altered splicing …

Pan-cancer studies have transformed our understanding of recurrent somatic mutations that
contribute to cancer pathogenesisn however, there has yet to be a full investigation of the …

Tumor genomes are mosaics of somatic structural variants (SVs) that may contribute to the
activation of oncogenes or inactivation of tumor suppressors, for example, by altering gene …

A large database of copy number profiles from cancer genomes can facilitate the
identification of recurrent chromosomal alterations that often contain key cancer-related …

Global studies of transcript structure and abundance in cancer cells enable the systematic
discovery of aberrations that contribute to carcinogenesis, including gene fusions …

Somatic mutations in cancer genomes often show allelic imbalance (AI) of mutation
abundance between the genome and transcriptome, but there is not yet a systematic …

We here present a comparative genome, transcriptome and functional network analysis of
three human cancer cell lines (A431, U251MG and U2OS), and investigate their relation to …

The impact of somatic structural variants (SVs) on gene expression in cancer is largely
unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes …

Imbalanced expression of somatic alleles in cancer can suggest functional and selective
features, and can therefore indicate possible driving potential of the underlying genetic …