Conspectus Systemic administration of therapeutic agents has been the preferred approach
to treat most pathological conditions, in particular for cancer therapy. This treatment modality …

Chemotherapy is the traditional treatment for intermediate and late stage cancers. The
search for treatment options with minimal side effects has been ongoing for several years …

As an emerging drug carrier, hydrogels have been widely used for tumor drug delivery. A
hydrogel drug carrier can cause less severe side effects than systemic chemotherapy and …

Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery
and have found clinical use. Hydrogels can provide spatial and temporal control over the …

Throughout the last decade, interventions to engineer the immune system called
immunotherapy have revolutionized the fields of oncology and autoimmune disease …

Degradable and cell-compatible hydrogels can be designed to mimic the physical and
biochemical characteristics of native extracellular matrices and provide tunability of …

Advances in hydrogel design have revolutionized the way biomaterials are applied to
address biomedical needs. Hydrogels were introduced in medicine over 50years ago and …

Locoregional chemotherapy, especially using implantable hydrogel depots to sustainably
deliver chemotherapeutics at tumor site, has shown great potential for improving antitumor …

Chemotherapy is commonly associated with limited effectiveness and unwanted side effects
in normal cells and tissues, due to the lack of specificity of therapeutic agents to cancer cells …

Reconciling the conflicting needs for a prolonged circulation time, enhanced cellular uptake
by bulk tumor cells and cancer stem cells (CSCs), and extensive tumor tissue penetration …