Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems

A Ettenberg, HO Pettit, FE Bloom, GF Koob - Psychopharmacology, 1982 - Springer
The hypothesis that separate neural systems mediate the reinforcing properties of opiate
and psychomotor stimulant drugs was tested in rats trained to lever-press for IV injections of …
被引用次数：744 相关文章 所有 6 个版本
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Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

HO Pettit, A Ettenberg, FE Bloom, GF Koob - Psychopharmacology, 1984 - Springer
The hypothesis that separate neural systems mediate the reinforcing properties of opioid
and psychomotor stimulant drugs was tested by examining the role of mesolimbic dopamine …
被引用次数：842 相关文章 所有 10 个版本

On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine

DCS Roberts, ME Corcoran, HC Fibiger - Pharmacology Biochemistry and …, 1977 - Elsevier
The role of ascending noradrenergic (NA) and dopaminergic (DA) systems in intravenous
self-administration of cocaine in rats was investigated by examining the effects of 6 …
被引用次数：935 相关文章 所有 7 个版本

Opiate antagonists reduce cocaine but not nicotine self-administration

WA Corrigall, KM Coen - Psychopharmacology, 1991 - Springer
Rats were trained to self-administer cocaine in 1-h sessions on a fixed ratio 5 (FR5)
schedule of reinforcement. Acquisition was carried out at a unit dose of 0.3 mg/kg and …
被引用次数：183 相关文章 所有 9 个版本

Conditioned and unconditioned drug effects in relapse to opiate and stimulant drug self-administration

J Stewart - Progress in neuro-psychopharmacology and biological …, 1983 - Elsevier
1. Humans and laboratory animals given access to opiate and stimulant drugs frequently
become compulsive users of these drugs, and often, in spite of prolonged periods of …
被引用次数：158 相关文章 所有 4 个版本

Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat

FJ Vaccarino, FE Bloom, GF Koob - Psychopharmacology, 1985 - Springer
A quaternary derivative of naloxone, methyl naloxonium chloride (MN), was administered
intracerebrally to rats trained to self-administer heroin intravenously. Increases in …
被引用次数：237 相关文章 所有 7 个版本

Evaluation of the role of norepinephrine in the reinforcing effects of psychomotor stimulants in rhesus monkeys

WL Woolverton - Pharmacology Biochemistry and Behavior, 1987 - Elsevier
Rhesus monkeys were surgically prepared with intravenous catheters and allowed to self-
administer cocaine (0.03–0.1 mg/kg/injection) under a fixed-ratio 10 schedule of drug …
被引用次数：124 相关文章 所有 6 个版本

Pharmacological regulation of intravenous cocaine and heroin self-administration in rats: a variable dose paradigm

GJ Gerber, RA Wise - Pharmacology Biochemistry and Behavior, 1989 - Elsevier
Rats were trained to intravenously self-administer unit doses of cocaine or heroin. Constant
supplemental infusion of a portion of each rat's mean hourly intake increased the mean time …
被引用次数：173 相关文章 所有 6 个版本

Antagonist treatment in nucleus accumbers or periaqueductal grey affects heroin self-administration

WA Corrigall, FJ Vaccarino - Pharmacology Biochemistry and Behavior, 1988 - Elsevier
The role of opiate receptors in the periaqueductal grey and nucleus accumbers in
maintenance of intravenous herion self-administration was examined by means of …
被引用次数：101 相关文章 所有 6 个版本

Neural mechanisms of drug reinforcement.

GF Koob - Annals of the new York Academy of Sciences, 1992 - europepmc.org
The brain substrates involved in the effect of cocaine on brain stimulation reward, in the
psychomotor activation associated with cocaine, and in cocaine self-administration appear …
被引用次数：882 相关文章 所有 7 个版本