Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the
remnant kidney model. Increasing evidence supports a role of glomerular cell proliferation in …

Platelet-derived growth factor (PDGF) is a potent mitogen for cells of mesenchymal origin
and is released and/or synthesized by platelets, macrophages, endothelial cells, and rat …

Proliferation of mesangial cells and expansion of mesangial matrix are common histologic
features of proliferative glomerular disease, a frequent cause of renal failure. Proliferation of …

Demonstration of PDGF B-chain mRNA in glomeruli in mesangial proliferative nephritis by in
situ hybridization. We used the technique of in situ hybridization to determine if cells …

Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized
rats. The 5/6 nephrectomy model is used to study pathogenetic mechanisms underlying …

PDGF-C is a new member of the PDGF-family and has recently been identified as a rat
mesangial cell mitogen. Its expression and function in human kidneys is unknown …

Platelet-derived growth factor-C (PDGF-C) is a new member of the PDGF family. Its
expression in normal and diseased kidney is unknown. Rabbit antisera were generated …

Platelet-derived growth factor receptors in the kidney—Upregulated expression in
inflammation. Major features of a long-standing inflammation in the kidney are vascular …

Progressive renal diseases represent a global medical problem, in part because we
currently lack effective treatment strategies. Inhibition of platelet-derived growth factors …

Mesangial cell (MC) proliferation and extracellular matrix expansion are involved in the
pathogenesis of glomerulosclerosis and renal failure. In vitro, PDGF and basic fibroblast …