SETTING: Host genetic risk factors influence susceptibility to tuberculosis (TB). There is
ample evidence supporting the involvement of toll-like receptor 4 (TLR4) in mycobacterial …

Background Genetic factors are important contributors to the development of a wide range of
complex disease. Polymorphisms in genes encoding for toll-like receptors (TLRs) usually …

Tuberculosis (TB) is a global public health problem and a source of preventable deaths
each year, with 8.8 million new cases of TB and 1.6 million deaths worldwide in 2005 …

Background: Tuberculosis is still a health problem throughout the world. Both genetic and
environmental factors may contribute the susceptibility to tuberculosis. Toll-like receptors …

Some evidence suggests that a variety of genetic factors contribute to development of the
tuberculosis (TB). TLR4 and TLR9 have been proposed as susceptibility genes for TB. This …

Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is a major cause of
morbidity and mortality worldwide. Many candidate genes have been investigated for a …

Background It is well known that toll-like receptor 2 (TLR2) mediates responses of both
innate and adaptive immunity to microbial pathogen, including mycobacteria. Single …

Despite high rates of exposure, only 5–10% of people infected with Mycobacterium
tuberculosis will develop active tuberculosis (TB) disease, suggesting a significant role for …

Background: It has been reported that one single nucleotide polymorphisms (SNPs)
rs5743708 in TLR2 gene might be associated with the susceptibility to tuberculosis disease …

Tuberculosis (TB) affects human life globally for a long time. The difference in clinical
outcome of infection suggests that host genetic makeup is responsible for such variability …