The specificity of cytotoxic T lymphocytes (Tc) cells is conferred by an antigen-specific
receptor, Ti, which in humans is physically associated with an invariant cell-surface …

It would be advantageous in the case of certain diseases to be able to focus a strong T-cell
response at a chosen target, for example, in treating cancer or infections that have escaped …

Mature human T lymphocytes can be separated by monoclonal antibodies OKT4 and OKT8
according to their surface phenotypes into T4+ T8− and T4− T8+ subsets1, 2. From shortterm …

Experiments using conventional antisera1, 2 and monoclonal antibodies3–5 have shown
that there are two functionally distinct human T-cell subsets which express unique cell …

The receptors found on most T lymphocytes bind to antigen presented on major
histocompatibility complex proteins and consist of dimers of α-and β-polypeptides …

It is possible to regulate the activity of human influenza virus specific helper T-cell clones
either by high concentrations of antigen1 or by anti-idiotypic suppressor T cells2. In the …

Activation of resting T lymphocytes is initiated by the interaction of cell-surface receptors with
their corresponding ligands. In addition to activation through the CD3 (T3)-Ti antigen …

Abstract THE CD8 glycoprotein of T cells binds nonpolymorphic regions of class I major
histocompatibility complex proteins on target cells1, 2 and these interactions promote …

Abstract ACTIVATION of CD4+ T helper cells results from the occupancy of the T-cell
receptor (TCR) by immunogenic peptide bound to a class II major histocompatibility complex …

CELL mediated immune reactions in mice involving cytotoxic thymus derived lymphocytes
have two important features; they are antigen-specific1 and the structures coded for by the …