After nitrogen, fluorine occupies the position of second favorite heteroelement in life science-
oriented research. In contrast, the trifluoromethoxy group is still perhaps the least well …

The last two decades have witnessed a tremendous growth of interest in fluoroorganic
compounds.'Numerous treatises on this subject covered various aspects of the chemistry …

One of the important applications of fluorinated organic compounds is in medicinal
chemistry. Recent progress in organofluorine chemistry has contributed significantly to the …

Fluorinated organic-compounds, 1 in particular those containing nitrogen atoms, 2 are most
important targets both in chemical and in biochemical chemistry. Interest in the formation of …

Drug candidates with one or more fluorines have become commonplace. The special nature
of fluorine imparts a variety of properties to certain medicines, including enhanced binding …

Advances in the development of newly developed fluorinated drugs, approved or in clinical
trials, as organized by biological targets/disease states, are reviewed. In a few cases …

This review will be devoted to a description of selectively fluorinated biologically active
molecules. Selective fluorination has been an extremely effective tool for modifying …

The natural abundance of fluorine as fluorite, fluoroapatite, and cryolite is considered to be
at the same level as that of nitrogen on the basis of the Clarke number of 0.03. However …

Since 1970 we developed three novel methods of fluoro‐organic synthesis in our laboratory,
namely: photofluorination (R‐H→‐F); fluorodehydrozylation (R‐OH→‐F); …

After nitrogen, fluorine is probably the next most favorite hetero-atom for incorporation into
small molecules in life science-oriented research. This review focuses on a particular …