Hyperglucagonemia is one of the 'ominous' eight factors underlying the pathogenesis of type
2 diabetes (T2D). Glucagon is a peptide hormone involved in maintaining glucose …

The opposite effects of insulin and glucagon in fuel homeostasis, the paracrine/endocrine
inhibitory effects of insulin on glucagon secretion and the hyperglucagonemia in the …

Discovered almost simultaneously with insulin, glucagon is a pleiotropic hormone with
metabolic action that goes far beyond its classical role to increase blood glucose. Albeit best …

Objective: There is general recognition that insulin and glucagon are the main hormones
involved in the pathophysiology of diabetes, but the role of glucagon in diabetes is complex …

Glucagon is secreted from the α-cells of the pancreatic islets and regulates glucose
homeostasis through modulation of hepatic glucose production. As elevated glucagon levels …

Excessive production of glucose by the liver contributes to fasting and postprandial
hyperglycaemia, hallmarks of type 2 diabetes. A central feature of this pathologic response …

The peptide hormone glucagon, discovered in late 1922, is secreted from pancreatic alpha
cells and is an essential regulator of metabolic homeostasis. This review summarises …

Type 2 diabetes mellitus is the result of impaired systemic control of glucose homeostasis, in
part through the dysregulation of the hormone glucagon. Glucagon acts on the liver to …

Glucagon is a hormone secreted from the alpha cells of the pancreatic islets. Through its
effect on hepatic glucose production (HGP), glucagon plays a central role in the regulation of …

Insulin and glucagon exert opposing effects on glucose metabolism and, consequently,
pancreatic islet β-cells and α-cells are considered functional antagonists. The intra-islet …