New challenges for pharmaceutical formulations and drug delivery systems characterization using isothermal titration calorimetry

K Bouchemal - Drug discovery today, 2008 - Elsevier
Long viewed as the 'method of choice'for characterizing thermodynamics and stoichiometry
of molecular interactions, with high sensitivity, isothermal titration calorimetry (ITC) has been …

Survey of the year 2009: applications of isothermal titration calorimetry

RJ Falconer, BM Collins - Journal of molecular recognition, 2011 - Wiley Online Library
Isothermal titration calorimetry (ITC) is now an established and invaluable method for
determining the thermodynamic constants, association constant and stoichiometry of …

Isothermal titration calorimetry (ITC) as a promising tool in pharmaceutical nanotechnology

IDL Cavalcanti, FHX Junior, NSS Magalhães… - International Journal of …, 2023 - Elsevier
Isothermal titration calorimetry (ITC) is a technique for evaluating the thermodynamic profiles
of connection between two molecules, allowing the experimental design of nanoparticles …

Application of isothermal titration calorimetry as a tool to study natural product interactions

O Callies, AH Daranas - Natural product reports, 2016 - pubs.rsc.org
Covering: up to February 2015 Over the past twenty-five years, isothermal titration
calorimetry (ITC) has become a potent tool for the study a great variety of molecular …

Differential scanning calorimetry: An invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions

MH Chiu, EJ Prenner - Journal of Pharmacy and Bioallied …, 2011 - journals.lww.com
Abstract Differential Scanning Calorimetry (DSC) is a highly sensitive technique to study the
thermotropic properties of many different biological macromolecules and extracts. Since its …

Thermodynamic properties of hydroxypropyl-β-cyclodextrin/guest interaction: a survey of recent studies

F D'Aria, B Pagano, C Giancola - Journal of Thermal Analysis and …, 2022 - Springer
For many years, cyclodextrins (CDs) have been the object of attention for their capability of
improving the stability, solubility and bioavailability of numerous molecules of interest …

Isothermal titration calorimetry: practical approaches and current applications in soft matter

WR Archer, MD Schulz - Soft Matter, 2020 - pubs.rsc.org
Isothermal Titration Calorimetry (ITC) elucidates the thermodynamic profile (ΔH, ΔS, ΔG, Ka,
and stoichiometry) of binding and dissociation reactions in solution. While ITC has primarily …

A survey of the year 2007 literature on applications of isothermal titration calorimetry

S Bjelić, I Jelesarov - Journal of Molecular Recognition, 2008 - Wiley Online Library
Elucidation of the energetic principles of binding affinity and specificity is a central task in
many branches of current sciences: biology, medicine, pharmacology, chemistry, material …

How to conduct and interpret ITC experiments accurately for cyclodextrin–guest interactions

K Bouchemal, S Mazzaferro - Drug Discovery Today, 2012 - Elsevier
Isothermal titration calorimetry (ITC) is one of the most interesting methods for the
characterization of the interaction mechanisms of cyclodextrins (CDs) with drugs. In this …

Making cool drugs hot: isothermal titration calorimetry as a tool to study binding energetics.

GA Holdgate - Biotechniques, 2001 - europepmc.org
Characterization of the thermodynamics of binding interactions is important in improving our
understanding of bimolecular recognition and forms an essential part of the rational drug …