Purpose: Pituitary adenomas are the second most common primary brain tumor, yet their
genetic profiles are incompletely understood. Experimental Design: We performed whole …

Pituitary tumors are the second most common adult primary brain tumor, with a variable
clinical course. Recent work has identified a number of genetic determinants of pituitary …

Purpose: Pituitary adenomas are one of the most common benign neoplasms of the central
nervous system. Although emerging evidence suggests roles for both genetic and …

Pituitary adenomas (PAs) are one of the most common intracranial tumors, which can result
in significant morbidity and can cause mortality either by exerting central pressure effects …

Background Pituitary adenomas (PAs) are commonly occurring neoplasms with diverse
endocrine and neurological effects. Although somatic gene mutations are uncommon in …

Context: The somatic landscape of pituitary adenomas is largely unknown. Identification of
somatic alterations aims at better understanding of tumor pathology. Objective: The objective …

Context: The tumorigenic role of genetic abnormalities in sporadic pituitary nonfunctioning
adenomas (NFAs), which usually originate from gonadotroph cells, is unknown. Objective …

Pituitary tumours are common intracranial neoplasms that cause significant morbidity
through mass effects and/or the inappropriate secretion of pituitary hormones. Despite a …

Although recent molecular investigations have identified a number of genetic alterations that
are associated with the development of pituitary adenomas, the exact pathogenesis …

Pituitary adenomas comprise 10% of intracranial tumors and occur in about 20% of the
population. They cause significant morbidity by compression of regional structures or the …