Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

A Alrubayyi, E Gea-Mallorquí, E Touizer… - Nature …, 2021 - nature.com
There is an urgent need to understand the nature of immune responses against SARS-CoV-
2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that …

Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition

T Nkosi, C Chasara, AO Papadopoulos, TL Nguni… - Elife, 2022 - elifesciences.org
In some instances, unsuppressed HIV has been associated with severe COVID-19 disease,
but the mechanisms underpinning this susceptibility are still unclear. Here, we assessed the …

Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-COV-2 infection

MJ Peluso, MA Spinelli, TM Deveau, CA Forman… - Aids, 2022 - journals.lww.com
Background: Limited data are available on the long-term clinical and immunologic
consequences of SARS-CoV-2 infection in people with HIV (PWH). Methods: We measured …

Immunologic interplay between HIV/AIDS and COVID-19: adding fuel to the flames?

M Augello, V Bono, R Rovito, C Tincati… - Current HIV/AIDS …, 2023 - Springer
Abstract Purpose of Review HIV/AIDS and COVID-19 have been the major pandemics
overwhelming our times. Given the enduring immune disfunction featuring people living with …

SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency

Y Li, MC Choudhary, J Regan, J Boucau… - Science translational …, 2024 - science.org
Despite vaccination and antiviral therapies, immunocompromised individuals are at risk for
prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but the …

[HTML][HTML] COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses

A Bonifacius, S Tischer-Zimmermann, AC Dragon… - Immunity, 2021 - cell.com
Cellular and humoral immunity to SARS-CoV-2 is critical to control primary infection and
correlates with severity of disease. The role of SARS-CoV-2-specific T cell immunity, its …

COVID-19 outcomes and risk factors among people living with HIV

MA Spinelli, BLH Jones, M Gandhi - Current HIV/AIDS Reports, 2022 - Springer
Abstract Purpose of Review In this review, we examine the intersection of the HIV and
COVID-19 epidemics with focus on COVID-19-related health outcomes and risk factors for …

The immune response to SARS-CoV-2 in people with HIV

MA Höft, WA Burgers, C Riou - Cellular & Molecular Immunology, 2024 - nature.com
This review examines the intersection of the HIV and SARS-CoV-2 pandemics. People with
HIV (PWH) are a heterogeneous group that differ in their degree of immune suppression …

HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave

F Karim, I Gazy, S Cele, Y Zungu, R Krause… - Elife, 2021 - elifesciences.org
There are conflicting reports on the effects of HIV on COVID-19. Here, we analyzed disease
severity and immune cell changes during and after SARS-CoV-2 infection in 236 …

[HTML][HTML] Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels

TM Snyder, RM Gittelman, M Klinger, DH May… - MedRxiv, 2020 - ncbi.nlm.nih.gov
T cells are involved in the early identification and clearance of viral infections and also
support the development of antibodies by B cells. This central role for T cells makes them a …