[HTML][HTML] Bile acids are important direct and indirect regulators of the secretion of appetite-and metabolism-regulating hormones from the gut and pancreas

RE Kuhre, NJW Albrechtsen, O Larsen, SL Jepsen… - Molecular …, 2018 - Elsevier
Abstract Objective Bile acids (BAs) facilitate fat absorption and may play a role in glucose
and metabolism regulation, stimulating the secretion of gut hormones. The relative …

Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1

S Katsuma, A Hirasawa, G Tsujimoto - Biochemical and biophysical …, 2005 - Elsevier
Bile acids play essential roles in the absorption of dietary lipids and in the regulation of bile
acid biosynthesis. Recently, a G protein-coupled receptor, TGR5, was identified as a cell …

Effects of rectal administration of taurocholic acid on glucagon‐like peptide‐1 and peptide YY secretion in healthy humans

T Wu, MJ Bound, SD Standfield… - Diabetes, Obesity …, 2013 - Wiley Online Library
Glucagon‐like peptide‐1 (GLP‐1) and peptide YY (PYY), secreted by enteroendocrine L‐
cells located most densely in the colon and rectum, are of fundamental importance in blood …

Central anorexigenic actions of bile acids are mediated by TGR5

A Perino, LA Velázquez-Villegas, N Bresciani… - Nature …, 2021 - nature.com
Bile acids (BAs) are signalling molecules that mediate various cellular responses in both
physiological and pathological processes. Several studies report that BAs can be detected …

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

CB Christiansen, SAJ Trammell… - American Journal …, 2019 - journals.physiology.org
A large number of glucagon-like-peptide-1 (GLP-1)-and peptide-YY (PYY)-producing L cells
are located in the colon, but little is known about their contribution to whole body …

The role of bile acids in glucose metabolism and their relation with diabetes

JA González-Regueiro, L Moreno-Castañeda… - Annals of …, 2018 - medigraphic.com
Bile acids (BAs), the end products of cholesterol catabolism, are essential for the absorption
of lipids and fat-soluble vitamins; but they have also emerged as novel signaling molecules …

The role of bile acids in metabolic regulation

L Vítek, M Haluzík - Journal of endocrinology, 2016 - joe.bioscientifica.com
Bile acids (BA), long believed to only have lipid-digestive functions, have emerged as novel
metabolic modulators. They have important endocrine effects through multiple cytoplasmic …

Mechanisms in endocrinology: bile acid sequestrants in type 2 diabetes: potential effects on GLP1 secretion

DP Sonne, M Hansen, FK Knop - European journal of …, 2014 - academic.oup.com
Bile acid sequestrants have been used for decades for the treatment of
hypercholesterolaemia. Sequestering of bile acids in the intestinal lumen interrupts …

Molecular mechanisms underlying bile acid‐stimulated glucagon‐like peptide‐1 secretion

HE Parker, K Wallis, CW Le Roux… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE The glucagon‐like peptides GLP‐1 and GLP‐2 are
secreted from enteroendocrine L‐cells following nutrient ingestion. Drugs that increase …

Role of bile acids in the regulation of food intake, and their dysregulation in metabolic disease

C Xie, W Huang, RL Young, KL Jones, M Horowitz… - Nutrients, 2021 - mdpi.com
Bile acids are cholesterol-derived metabolites with a well-established role in the digestion
and absorption of dietary fat. More recently, the discovery of bile acids as natural ligands for …