Functional characterization of HLA‐F and binding of HLA‐F tetramers to ILT2 and ILT4 receptors

EJM Lepin, JM Bastin, DSJ Allan… - European journal of …, 2000 - Wiley Online Library
HLA‐F is a human non‐classical MHC molecule. Recombinant HLA‐F heavy chain was
refolded with β2‐microglobulin to form a stable complex. This complex was used as an …

HLA-F complex without peptide binds to MHC class I protein in the open conformer form

JP Goodridge, A Burian, N Lee… - The Journal of …, 2010 - journals.aai.org
HLA-F has low levels of polymorphism in humans and is highly conserved among primates,
suggesting a conserved function in the immune response. In this study, we probed the …

HLA‐F is a surface marker on activated lymphocytes

N Lee, A Ishitani, DE Geraghty - European journal of …, 2010 - Wiley Online Library
Of the three nonclassical class I antigens expressed in humans, HLA‐F has been least
characterized with regard to expression or function. In this study, we examined HLA‐F …

Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function

T Gonen-Gross, H Achdout, R Gazit… - The Journal of …, 2003 - journals.aai.org
The nonclassical class I MHC molecule HLA-G is selectively expressed on extravillous
cytotrophoblast cells at the maternal-fetal interface during pregnancy. HLA-G can inhibit the …

HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern

SD Wainwright, PA Biro, CH Holmes - The Journal of Immunology, 2000 - journals.aai.org
HLA-F is currently the most enigmatic of the human MHC-encoded class Ib genes. We have
investigated the expression of HLA-F using a specific Ab raised against a synthetic peptide …

Structure and function of the human MHC class Ib molecules HLA‐E, HLA‐F and HLA‐G

CA O'Callaghan, JI Bell - Immunological reviews, 1998 - Wiley Online Library
The major histocompatibility (MHC) class Ib molecules HLA‐E, HIA‐F and HLA‐G are
relatively non‐polymorphic compared to class la molecules. Both HLA‐E and HLA‐G bind …

Tetrameric complexes of HLA-E, HLA-F, and HLA-G

DSJ Allan, EJM Lepin, VM Braud… - Journal of …, 2002 - Elsevier
HLA-E, HLA-F, and HLA-G are human nonclassical MHC class Ib molecules. To study the
function and identify potential ligands of these molecules, we constructed tetrameric …

Structural studies on HLA-G: implications for ligand and receptor binding

CS Clements, L Kjer-Nielsen, J McCluskey… - Human immunology, 2007 - Elsevier
Human leukocyte antigen-G (HLA-G) is a class Ib major histocompatibility complex (MHC)
molecule that is specifically expressed in immune-privileged tissues. The overall structure of …

The tolerogenic molecule HLA-G

ED Carosella - Immunology letters, 2011 - Elsevier
Three recent publications review the basic immunological, clinical, and regulation aspects of
HLA-G [1–3]. Briefly, HLA-G is characterized by a low amount of polymorphism and a …

Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors

KY HoWangYin, M Loustau, J Wu, E Alegre… - Cellular and Molecular …, 2012 - Springer
The non-classical Human leukocyte antigen G (HLA-G) differs from classical HLA class I
molecules by its low genetic diversity, a tissue-restricted expression, the existence of seven …