Determinants of immune complex-mediated glomerulonephritis. We have studied the
influence of steric factors on the clinico-pathologic expression of immune complex-mediated …

The passive trapping of preformed immune complexes is responsible for some forms of
glomerulonephritis that are associated with mesangial or subendothelial deposits. The …

Quantitative and qualitative studies of antibody–induced mesangial cell damage in the rat.
Intravenous administration of heterologous anti-rat thymocyte serum (ATS), which reacts …

The membrane attack complex—also known as C5b-9—is the end-product of the classical,
lectin, and alternative complement pathways. It is thought to play an important role in the …

The generation of autoantibody and subsequent tissue deposition of immune complexes
(IC) is thought to trigger the pathogenic consequences of systemic autoimmune disease …

The participation of immune processes in the production of glomerular injury is generally
accepted. The ability of the immunopathologist to readily identify and differentiate various …

Cationized human IgG can bind to the rat glomerular basement membrane (GBM), act as
planted antigen, and induce in situ immune complex formation accompanied by severe …

Complement-mediated injury reversibly disrupts glomerular epithelial cell actin
microfilaments and focal adhesions. Background Foot process effacement and …

This review summarizes current understanding of the mechanisms which mediate immune
glomerular injury in glomerulonephritis. Non-inflammatory lesions resembling minimal …